韩国淫羊藿（学名：Epimedium koreanum Nakai，简称：E. koreanum）是小檗科淫羊藿属的一种著名传统草药，在几千年的历史中被广泛用作“补肾良药”。它被应用于肾阳虚、阳痿、遗精、腰膝酸软、风湿瘫痪、麻木、拘挛等症状。本文旨在对韩国淫羊藿的传统应用、植物化学、药理学和毒性进行全面深入、系统性的综述。我们在Web of Science、PubMed、Google Scholar、Elsevier、Springer、ScienceDirect、百度学术和中国知网等科学数据库以及中国的医学书籍中搜索与韩国淫羊藿相关的信息。在传统用途方面，韩国淫羊藿常被用来治疗阳痿、不育、类风湿关节炎、骨质疏松症、哮喘、肾阳虚等多种疾病。到目前为止，我们已经从韩国淫羊藿的各个部位分离出了379个化合物，包括黄酮类、木脂素、有机酸、萜类物质、烃类、二氢苯并吲哚衍生物、生物碱等。研究发现，这些化合物和粗提物在生殖、心血管和神经系统以及抗骨质疏松、抗肿瘤、抗氧化、抗炎、免疫调节、肝保护和抗病毒等方面具有广泛的药理作用。此外，粗提物还显示出潜在的肝毒性。基于国内外最新研究调查，韩国淫羊藿含有丰富的化学成分，具有显著的药理活性。大部分传统用途也得到了当代药理学研究的支持。然而，粗提物可能导致肝毒性。因此，未来需要进行更多的体内和体外实验研究，以评估韩国淫羊藿的安全性和有效性。这将为其安全应用和未来新药开发提供更为坚实的科学基础。版权 © 2023，Elsevier B.V. 发表。

Epimedium koreanum Nakai (E. koreanum), a member of the genus Epimedium in the family Berberidaceae, is a well-known and well-liked traditional herb used as a "kidney tonic". For thousands of years, it has been utilized for renal yang deficiency, impotence, spermatorrhea, impotence, weakness of tendons and bones, rheumatic paralysis and discomfort, numbness, and constriction.The paper aims to comprehensively in-depth, and methodically review the most recent research on the traditional uses, phytochemistry, pharmacology, and toxicity of E. koreanum.Scientific databases including Web of Science, PubMed, Google Scholar, Elsevier, Springer, ScienceDirect, Baidu Scholar, and CNKI and medicine books in China were searched for relevant information on E. koreanum.In traditional uses, E. koreanum is frequently used to treat various diseases like erectile dysfunction, infertility, rheumatoid arthritis, osteoporosis, asthma, kidney-yang deficiency syndrome, etc. To date, more than 379 compounds have been discovered from various parts of E. koreanum, including flavonoids, lignans, organic acids, terpenoids, hydrocarbons, dihydrophenanthrene derivatives, alkaloids, and others. Research has revealed that the compounds and crude extracts have a wide range of pharmacological effects on the reproductive, cardiovascular, and nervous systems, as well as anti-osteoporosis, anti-tumor, antioxidant, anti-inflammatory, immunomodulatory, hepatoprotective, and antiviral properties. Besides, the crude extracts show potential hepatotoxicity.Based on recent domestic and international research investigations, E. koreanum contains a wealth of chemical components with pronounced pharmacological activities. Its traditional uses are numerous, and the majority of these traditional uses have been supported by contemporary pharmacological investigations. Crude extracts, on the other hand, can result in hepatotoxicity. Therefore, additional in vivo and in vitro experimental research on the pharmacology and toxicology of E. koreanum are required in the future to assess its safety and efficacy. This will give a firmer scientific foundation for its safe application and the development of new drugs in the future.Copyright © 2023. Published by Elsevier B.V.