南非金头草注入液被用作利尿剂和出汗剂，同时也用于治疗胃肠疾病和妇科问题、炎症和皮肤疾病、哮喘、咳嗽、发热和疼痛性疾病。该植物传统上被用作治疗炎症和皮肤问题的药物。研究金头草精油（EAEO）作为一种潜在的保肝措施，用于对Concanavalin（Con） A诱导的小鼠肝炎的治疗，并研究其潜在机制。将鲜植物空中部分的蒸馏油进行GC/MS分析。通过静脉注射Con A（15mg/kg）在小鼠体内诱导自身免疫性肝炎（AIH）。在Con A注射之前口服EAEO以测试其保肝活性。GC/MS分析显示油中存在22种化合物，占油的99.43%。单萜烯青蒿酮（41.02%）和倍半蒿酮（14.17%）是主要成分。体内研究显示该油抑制了Con A诱导的中性粒细胞和CD4+T细胞对肝脏的浸润，恢复了肝脏氧化还原平衡，抑制了Con A诱导的肝内肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和干扰素-γ（IFN-γ）水平的升高，这与其抑制肝脏核因子κB（NF-κB）和信号传导转录激活因子-1（STAT1）的激活能力相关。EAEO通过选择性的抗氧化、抗炎和抗坏死效应在小鼠中显示出对Con A诱导的肝炎的保肝潜力。版权所有 © 2023. 由Elsevier B.V.出版。

Eriocephalus africanus infusion is used as a diuretic and a diaphoretic and is also used in the treatment of gastrointestinal disorders and gynaecological conditions, inflammation and dermal disorders, asthma, coughs, fevers, and painful ailments. The plant has been used traditionally as a medication to cure inflammation and skin problems.Studying E. africanus essential oil (EAEO) as a potential hepatoprotective measure against concanavalin (Con) A-induced hepatitis in mice and investigating its underlying mechanism.Hydro-distilled oil of the fresh plant aerial shoots is subjected to GC/MS analysis. Autoimmune hepatitis (AIH) was induced in mice by intravenous injection of Con A (15 mg/kg). EAEO was administered orally before Con A injection to test its hepatoprotective activity.GC/MS analysis revealed the presence of 22 compounds representing 99.43% of the oil. The monoterpene artemisia ketone (41.02%) and the sesquiterpene juniper camphor (14.17%) are the major components. The in vivo study showed that the oil suppressed Con A-induced neutrophil and CD4+T cell infiltration into the liver, restored hepatic redox balance, inhibited Con A-induced elevation of tumor necrosis factor-alpha (TNF-α), interleukin (IL-6), and interferon-gamma (IFN-γ) hepatic levels which were correlated with its ability to suppress nuclear factor kappa B (NF-κB) and Signal Transducer and Activator of Transcription (STAT1) activation in the liver.EAEO showed hepatoprotective potential against Con A-induced hepatitis in mice collectively through selective anti-oxidant, anti-inflammatory, and anti-necrotic effects.Copyright © 2023. Published by Elsevier B.V.