血管新生是器官和组织形态发生以及人类发育过程中的关键过程，由血管生成和抑制的因子进行协调。当这种平衡受到影响时，相关的生理和病理变化会导致疾病发生。长链非编码RNA（lncRNA）是一类不编码蛋白质但在基因表达调控中发挥动态作用的重要非编码RNA。已报道了lncRNA在血管新生中的广泛参与，特别是肿瘤血管生成。然而，非肿瘤方面的研究报道较少，但在lncRNA靶向血管新生方面仍有较大的研究和探索空间。本综述重点关注肿瘤以外与血管新生相关的疾病中的lncRNA，如动脉粥样硬化、心肌梗死、中风、糖尿病并发症、高血压、骨质疏松、皮肤病，以及内分泌、神经和其他系统性疾病。此外，多种细胞类型已被认为与lncRNA靶向血管新生有关，但仅内皮细胞受到了广泛关注。因此，我们探究了其他细胞的角色。最后，通过结合尖端技术和跨学科研究，总结了lncRNA与血管新生领域的潜在研究方向，这将为了解lncRNA在与血管新生相关的疾病中的作用提供新的见解。版权所有© 2023. Elsevier Inc.出版。

Angiogenesis is a key process in organ and tissue morphogenesis, as well as growth during human development, and is coordinated by pro- and anti-angiogenic factors. When this balance is affected, the related physiological and pathological changes lead to disease. Long non-coding RNAs (lncRNAs) are an important class of non-coding RNAs that do not encode proteins, but play a dynamic role in regulating gene expression. LncRNAs have been reported to be extensively involved in angiogenesis, particularly tumor angiogenesis. The non-tumor aspects have received relatively little attention and summary, but there is a broad space for research and exploration on lncRNA-targeted angiogenesis in this area. In this review, we focus on lncRNAs in angiogenesis-related diseases other than tumors, such as atherosclerosis, myocardial infarction, stroke, diabetic complications, hypertension, osteoporosis, dermatosis, as well as, endocrine, neurological, and other systemic disorders. Moreover, multiple cell types have been implicated in lncRNA-targeted angiogenesis, but only endothelial cells have attracted widespread attention. Thus, we explore the roles of other cells. Finally, we summarize the potential research directions in the area of lncRNAs and angiogenesis that can be undertaken by combining cutting-edge technology and interdisciplinary research, which will provide new insights into the involvement of lncRNAs in angiogenesis-related diseases.Copyright © 2023. Published by Elsevier Inc.