内分泌干扰化学物质（EDCs）是有害化合物，它们通过自然途径或人类活动进入环境，并扰乱人类正常的内分泌功能，对生殖健康造成不利影响。制药、化妆品和包装行业是EDC污染物最重要的来源之一。已经确定，EDCs对男性生殖系统产生恶化效应，这一点由越来越多的男性不育病例所证实。已经发表了大量的个案研究，这些研究指出，暴露于EDCs的男性出现睾丸癌、未降丸、血清睾酮水平下降和精液质量降低。此外，流行病学证据表明，产前暴露于EDCs与婴儿阴囊未降或睾丸下降、尿道下裂以及肛生殖距离缩短存在关联性。然而，由于缺乏长期随访研究，这些发现的大部分并不一致，这些研究结果无法证明EDCs与男性生殖紊乱有关。本综述旨在概述关于EDCs与男性生殖健康关联的最新科学进展，特别强调其毒性和扰乱男性生殖系统的可能机制。版权所有 © 2023。Elsevier公司出版。

Endocrine Disrupting Chemicals (EDCs) are harmful compounds that enter the environment naturally or through anthropogenic activities and disrupt normal endocrine functions in humans, adversely affecting reproductive health. Among the most significant sources of EDC contaminants are the pharmaceutical, cosmetic, and packaging industries. EDCs have been identified to have a deteriorating effect on male reproductive system, as evidenced by the increasing number of male infertility cases. A large number of case studies have been published in which men exposed to EDCs experienced testicular cancer, undescended testicles, a decrease in serum testosterone levels, and poor semen quality. Furthermore, epidemiological evidence suggested a link between prenatal EDC exposure and cryptorchidism or undescended testicles, hypospadias, and decreased anogenital distance in infants. The majority of these findings, however, are incongruent due to the lack of long-term follow-up studies that would demonstrate EDCs to be associated with male reproductive disorders. This review aims to provide an overview on recent scientific progress on the association of EDCs to male reproductive health with special emphasis on its toxicity and possible mechanism of EDCs that disrupt male reproductive system.Copyright © 2023. Published by Elsevier Inc.