天然多糖是天然生物材料，由于其出色的可降解性和生物相容性，已成为纳米药物递送系统的候选材料。铂（Pt）药物已广泛应用于临床治疗各种实体肿瘤。然而，它们广泛的系统毒性以及癌细胞获得的耐药性限制了铂类药物的应用。现代纳米生物技术为将铂类药物定向递送至肿瘤部位提供了可能性，从而最大限度地减少毒性并优化药物的效果。近年来，已开发了许多天然多糖-铂纳米药物递送载体，如纳米胶束、纳米球、纳米凝胶等。在这里，我们对近年来天然多糖-铂纳米药物的构建和药物释放进行了综述。同时，提出了该领域当前的挑战和未来的前景展望。总的来说，结合照射和肿瘤微环境为将来天然多糖-铂纳米药物的构建和响应药物释放提供了重要的研究方向。版权所有 © 2023，由Elsevier B.V.出版。

Natural polysaccharides are natural biomaterials that have become candidate materials for nano-drug delivery systems due to their excellent biodegradability and biocompatibility. Platinum (Pt) drugs have been widely used in the clinical therapy for various solid tumors. However, their extensive systemic toxicity and the drug resistance acquired by cancer cells limit the applications of platinum drugs. Modern nanobiotechnology provides the possibility for targeted delivery of platinum drugs to the tumor site, thereby minimizing toxicity and optimizing the efficacies of the drugs. In recent years, numerous natural polysaccharide-platinum nanomedicine delivery carriers have been developed, such as nanomicelles, nanospheres, nanogels, etc. Herein, we provide an overview on the construction and drug release of natural polysaccharide-Pt nanomedicines in recent years. Current challenges and future prospectives in this field are also put forward. In general, combining with irradiation and tumor microenvironment provides a significant research direction for the construction of natural polysaccharide-platinum nanomedicines and the release of responsive drugs in the future.Copyright © 2023. Published by Elsevier B.V.