本系统综述旨在从护理角度描述儿科患者进行嵌合抗原受体T细胞（CAR-T）输注的总体护理、患者和家长教育、人员培训和并发症管理情况，以提供对这些患者管理方法的最新总结。CAR-T细胞疗法是儿科血液学和肿瘤学领域的一种创新治疗方法，用于治疗复发和难治性白血病、实体肿瘤和淋巴瘤，当标准治疗无效时。然而，这种疗法可能引发一些临床并发症，必须适当和及时地进行管理。尽管其应用不断增加，但文献中的知识和资源仍然有限。本综述于2022年1月至2022年7月在PubMed、CINAHL、Scopus和Cochrane进行，共查得502篇文章。根据选择标准并删除重复文章，最终纳入研究的文章为26篇。通过对这些分析文章的分析，可以得到有关儿科患者进行CAR-T细胞输注的管理、患者和家长教育、人员培训和并发症管理情况的总览。从护理角度来看，血液肿瘤学患者进行CAR-T细胞疗法的管理并不简单。我们希望本综述能成为指导护理人员的工具。在这方面，我们编制了一张总结表，列出了在协助治疗儿科CAR-T患者时应采取的措施。版权所有 © 2023 Elsevier Inc.。保留所有权利。

This systematic review aims to describe an overview of the overall care, patient and parent education, staff training, and management of complications from a nursing perspective of pediatric patients undergoing chimeric antigen receptor T (CAR-T) cell infusion in order to provide an updated summary of the approach to the management of these patients. CAR-T cellular therapy represents an innovation within pediatric hematology and oncology used to treat relapse and refractory leukemias, solid tumors, and lymphomas when standard therapy has not worked. However, this type of therapy could lead to the onset of some clinical complications that must be managed appropriately and promptly. Although their use is constantly increasing, the knowledge and resources in the literature are still limited.The review was conducted from January 2022 to July 2022 in PubMed, CINAHL, Scopus, and Cochrane and produced 502 articles. Based on the selection criteria and after removing duplicate articles, 26 articles were included in the study.From these analyzed articles, it was possible to have an overview regarding the management, patient and parent education, staff training, and management of complications from a nursing perspective of pediatric patients undergoing CAR-T cell infusion.The management of hematology-oncology patients undergoing CAR-T cell therapy from a nursing perspective is not simple. We hope this review can be used as a tool to guide nursing staff. In this regard, we have developed a summary table with the actions to be taken in the case of assisting a pediatric patient being treated with CAR-T.Copyright © 2023 Elsevier Inc. All rights reserved.