CD4+ T细胞有助于髓系介导的免疫逃避肿瘤的杀伤作用。
CD4+ T cells help myeloid-mediated killing of immune-evasive tumors.
发表日期：2023 Aug 04
作者：
Kai Wu, Lawrence Fong
来源：
Trends in Cancer
摘要：
在最近发表于《自然》杂志的一项研究中，Kruse等人展示了一种由少量CD4+效应性T细胞协调的间接抗肿瘤机制。这些CD4+ T细胞能够重编程骨髓细胞，不仅转变为IFNγ诱导的抗原呈递细胞，还能转变为表达iNOS的肿瘤杀伤效应细胞，从而能够消除免疫逃逸肿瘤。
版权所有 © 2023 The Authors. 由爱思唯尔出版，保留所有权利。
In a recent study published in Nature, Kruse et al. demonstrated an indirect tumor-killing mechanism orchestrated by a small number of CD4+ effector T cells. These CD4+ T cells can reprogram myeloid cells not just into IFNγ-induced antigen-presenting cells but also into iNOS-expressing tumoricidal effectors that can eradicate immune-evasive tumors.Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.