转移性卵巢癌微环境主要以癌细胞和宿主细胞之间复杂的相互作用网络为特征。这种复杂的异种癌细胞-宿主细胞交互作用导致了一个促进癌细胞转移和治疗抵抗的环境，进而导致患者预后和生存率较差。在本综述中，我们重点关注卵巢癌微环境中的两种宿主细胞类型：间皮细胞和肿瘤相关巨噬细胞。间皮细胞构成腹腔器官的保护性衬里组织。癌细胞通过间皮细胞单层附着和侵袭，形成转移性病灶。间皮细胞与癌细胞之间的相互作用可促进转移进展和化疗抵抗。肿瘤相关巨噬细胞是卵巢癌微环境中最丰富的免疫细胞类型，并可极化为促肿瘤或抗肿瘤表型。巨噬细胞极化可受化疗和与癌细胞的相互作用影响，从而导致癌细胞侵袭和治疗抵抗。对癌-间皮和癌-巨噬细胞相互作用的更好理解将揭示转移进展的生物标志物和恢复化疗敏感性的治疗靶点。

The metastatic ovarian cancer microenvironment is characterized by an intricate interaction network between cancer cells and host cells. This complex heterotypic cancer-host cell crosstalk results in an environment that promotes cancer cell metastasis and treatment resistance, leading to poor patient prognosis and survival. In this review, we focus on two host cell types found in the ovarian cancer microenvironment: mesothelial cells and tumor associated macrophages. Mesothelial cells make up the protective lining of organs in the abdominal cavity. Cancer cells attach and invade through the mesothelial monolayer to form metastatic lesions. Crosstalk between mesothelial and cancer cells can contribute to metastatic progression and chemotherapy resistance. Tumor associated macrophages are the most abundant immune cell type in the ovarian cancer microenvironment and can be polarized to pro-tumor or anti-tumor phenotypes. Macrophage polarization can be influenced by chemotherapy and communication with cancer cells, resulting in cancer cell invasion and treatment resistance. A better understanding of cancer-mesothelial and cancer-macrophage crosstalk will uncover biomarkers of metastatic progression and therapeutic targets to restore chemotherapy sensitivity.