卵巢癌肿瘤微环境（TME）包括了众多的细胞组分、细胞外基质和可溶性因子。细胞外可溶性因子如细胞因子、化学因子、结构蛋白、细胞外囊泡和代谢产物是非接触型细胞间通讯的关键手段，它们作为信使传递着促癌或抗癌信号。我们持续取得了巨大的进展，了解了癌细胞如何调整代谢以满足环境需求，并利用这些适应性促进存活、转移和抗治疗性能。在这一过程中，间质TME对于代谢重塑的贡献相对较少被探索，特别是在卵巢癌中。因此，TME中的代谢活动变化在进一步研究和潜在的治疗利用中表现出了希望。在本综述中，我们重点关注TME的细胞组分，包括：1）卵巢癌的代谢特征；2）理解基质细胞网络及其与肿瘤细胞之间的代谢相互作用；以及3）基质和肿瘤细胞代谢产物如何改变肿瘤内免疫细胞的代谢和功能。这些元素共同揭示了TME的代谢影响，并强调了了解代谢性能如何推动癌症进展的重要性。

The ovarian cancer tumor microenvironment (TME) consists of a constellation of abundant cellular components, extracellular matrix, and soluble factors. Soluble factors such as cytokines, chemokines, structural proteins, extracellular vesicles, and metabolites are critical means of non-contact cellular communication acting as messengers to convey pro- or anti-tumorigenic signals. Vast advancements have been made in our understanding of how cancer cells adapt their metabolism to meet environmental demands and utilize these adaptations to promote survival, metastasis, and therapeutic resistance. The stromal TME contribution to this metabolic rewiring has been relatively underexplored, particularly in ovarian cancer. Thus, metabolic activity alterations in the TME hold promise for further study and potential therapeutic exploitation. In this review, we focus on the cellular components of the TME with emphasis on: 1) metabolic signatures of ovarian cancer; 2) understanding the stromal cell network and their metabolic crosstalk with tumor cells; and 3) how stromal and tumor cell metabolites alter intratumoral immune cell metabolism and function. Together, these elements provide insight into the metabolic influence of the TME and emphasize the importance of understanding how metabolic performance drives cancer progression.