肿瘤微环境(TME)是肿瘤进展的重要驱动因素,通过改变免疫细胞的代谢活动,它可以阻碍机体的免疫反应。肿瘤和免疫细胞通过转运体介导的营养摄取和代谢物外流来维持其增殖特性和生理功能。转运体在调节TME中的免疫应答中也发挥着重要作用。在本综述中,我们概述了TME的代谢特征,并系统阐述了丰富代谢物对免疫细胞功能和转运体表达的影响。我们还讨论了由于转运体功能失调而引起的肿瘤免疫逃逸机制。最后,我们介绍了一些靶向转运体的抗肿瘤治疗策略,旨在为临床癌症治疗的抗肿瘤药物开发和合理用药提供新的见解。版权所有 © 2023 陈、王、胡、刘、齐、唐、胡、林、曾和于。

The tumor microenvironment (TME) is a crucial driving factor for tumor progression and it can hinder the body's immune response by altering the metabolic activity of immune cells. Both tumor and immune cells maintain their proliferative characteristics and physiological functions through transporter-mediated regulation of nutrient acquisition and metabolite efflux. Transporters also play an important role in modulating immune responses in the TME. In this review, we outline the metabolic characteristics of the TME and systematically elaborate on the effects of abundant metabolites on immune cell function and transporter expression. We also discuss the mechanism of tumor immune escape due to transporter dysfunction. Finally, we introduce some transporter-targeted antitumor therapeutic strategies, with the aim of providing new insights into the development of antitumor drugs and rational drug usage for clinical cancer therapy.Copyright © 2023 Chen, Wang, Hu, Liu, Qi, Tang, Hu, Lin, Zeng and Yu.