肿瘤相关巨噬细胞（TAMs）是浸润肿瘤微环境（TME）的重要免疫细胞。最近的研究表明，TAMs在表型、功能、时间和空间分布方面存在多样性，这可进一步分类TAM亚型。脂肪酸氧化（FAO）的代谢效率在TAM亚型之间存在差异。FAO与活性氧产生物（ROS）的产生密切相关，而ROS在氧化应激等过程中发挥作用。目前的证据表明，FAO和ROS可以单独或结合影响TAM的招募、极化和吞噬能力，从而影响肿瘤的进展。但这些关系的具体机制仍需要进一步研究。我们将从ROS和TAM、FAO和TAM以及FAO、ROS和TAM的相互关系三个方面回顾关于TAM与肿瘤发展之间关系的最新研究进展。版权所有 © 2023 Teng, Xu, Li, Liu, Tian和Liu。

Tumor-associated macrophages (TAMs) are significant immunocytes infiltrating the tumor microenvironment(TME). Recent research has shown that TAMs exhibit diversity in terms of their phenotype, function, time, and spatial distribution, which allows for further classification of TAM subtypes. The metabolic efficiency of fatty acid oxidation (FAO) varies among TAM subtypes. FAO is closely linked to the production of reactive oxygen species (ROS), which play a role in processes such as oxidative stress. Current evidence demonstrates that FAO and ROS can influence TAMs' recruitment, polarization, and phagocytosis ability either individually or in combination, thereby impacting tumor progression. But the specific mechanisms associated with these relationships still require further investigation. We will review the current status of research on the relationship between TAMs and tumor development from three aspects: ROS and TAMs, FAO and TAMs, and the interconnectedness of FAO, ROS, and TAMs.Copyright © 2023 Teng, Xu, Li, Liu, Tian and Liu.