对肝细胞癌进展中Wnt/β-catenin信号通路和环形RNA相互作用的焦点研究。
A spotlight on the interplay between Wnt/β-catenin signaling and circular RNAs in hepatocellular carcinoma progression.
发表日期：2023
作者：
Alireza Mafi, Hamidreza Rismanchi, Mohaddese Malek Mohammadi, Neda Hedayati, Seyedeh Sara Ghorbanhosseini, Seyed Ali Hosseini, Yasaman Gholinezhad, Rohollah Mousavi Dehmordi, Behrooz Ghezelbash, Fatemeh Zarepour, Seyed Pouya Taghavi, Zatollah Asemi, Mina Alimohammadi, Hamed Mirzaei
来源：
Stem Cell Research & Therapy
摘要：
肝细胞癌（HCC）是一种最为致命的癌症之一，其多焦发展和远处转移常因晚期诊断而发生。因此，为了降低死亡率，需要开展新的HCC诊断和治疗方法。大量的证据表明，非编码RNA（ncRNA）在癌症的起始和进展中起着重要作用。癌细胞释放出许多这些ncRNAs至血液或尿液中，从而将其用作诊断工具。环状RNA（CircRNAs）作为ncRNAs家族的成员，通过不同机制，如Wnt/β-连环蛋白信号通路，调节癌细胞扩张、迁移、转移和化疗抗药性。Wnt/β-连环蛋白信号通路在多种生物过程中起到重要作用，包括器官发生、干细胞再生和细胞存活。上述两种通路的异常信号传导可能会影响包括HCC在内的许多癌症的进展和转移。根据本回顾研究调查的几项研究，circRNAs通过吸附miRNAs和RNA结合蛋白（RBPs）并调节Wnt/β-连环蛋白信号通路，对HCC的形成和进展产生影响。因此，circRNAs/miRNAs或RBPs/Wnt/β-连环蛋白信号通路可以被视为HCC的有前景的预后和治疗靶点。版权所有 © 2023 Mafi, Rismanchi, Malek Mohammadi, Hedayati, Ghorbanhosseini, Hosseini, Gholinezhad, Mousavi Dehmordi, Ghezelbash, Zarepour, Taghavi, Asemi, Alimohammadi和Mirzaei。
Hepatocellular carcinoma (HCC) is one of the deadliest cancers due to multifocal development and distant metastasis resulting from late diagnosis. Consequently, new approaches to HCC diagnosis and treatment are required to reduce mortality rates. A large body of evidence suggests that non-coding RNAs (ncRNAs) are important in cancer initiation and progression. Cancer cells release many of these ncRNAs into the blood or urine, enabling their use as a diagnostic tool. Circular RNAs (CircRNAs) are as a members of the ncRNAs that regulate cancer cell expansion, migration, metastasis, and chemoresistance through different mechanisms such as the Wnt/β-catenin Signaling pathway. The Wnt/β-catenin pathway plays prominent roles in several biological processes including organogenesis, stem cell regeneration, and cell survival. Aberrant signaling of both pathways mentioned above could affect the progression and metastasis of many cancers, including HCC. Based on several studies investigated in the current review, circRNAs have an effect on HCC formation and progression by sponging miRNAs and RNA-binding proteins (RBPs) and regulating the Wnt/β-catenin signaling pathway. Therefore, circRNAs/miRNAs or RBPs/Wnt/β-catenin signaling pathway could be considered promising prognostic and therapeutic targets in HCC.Copyright © 2023 Mafi, Rismanchi, Malek Mohammadi, Hedayati, Ghorbanhosseini, Hosseini, Gholinezhad, Mousavi Dehmordi, Ghezelbash, Zarepour, Taghavi, Asemi, Alimohammadi and Mirzaei.