N6-甲基腺嘌呤（m6A）是mRNA和lncRNA中最常见的内部修饰。它对RNA功能施加可逆调控，影响各种疾病中的RNA处理和代谢，尤其是肿瘤。m6A结合蛋白hnRNPA2B1广泛研究，并作为异质核糖核蛋白（hnRNP）蛋白家族的一员。它经常发生失调，在多种类型的肿瘤中具有重要意义。 hnRNPA2B1通过识别m6A位点进行可变剪接，维持RNA稳定性以及调节翻译和转运，对肿瘤发展、代谢以及免疫微环境的调节在各个方面起到至关重要的作用。在本综述中，我们总结了hnRNPA2B1的功能角色和潜在的分子机制的最新研究。此外，我们讨论了其作为肿瘤治疗靶点的潜力。版权所有©2023年吴某某、李某某、陈某某、方某某、陈某某和郑某某。

N6-methyladenosine (m6A) is the most prevalent internal modification found in both mRNA and lncRNA. It exerts reversible regulation over RNA function and affects RNA processing and metabolism in various diseases, especially tumors. The m6A binding protein, hnRNPA2B1, is extensively studied as a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) protein family. It is frequently dysregulated and holds significant importance in multiple types of tumors. By recognizing m6A sites for variable splicing, maintaining RNA stability, and regulating translation and transport, hnRNPA2B1 plays a vital role in various aspects of tumor development, metabolism, and regulation of the immune microenvironment. In this review, we summarized the latest research on the functional roles and underlying molecular mechanisms of hnRNPA2B1. Moreover, we discussed its potential as a target for tumor therapy.Copyright © 2023 Wu, Li, Chen, Fang, Chen and Zheng.