细胞毒性是使用化疗药物治疗癌症的一个关键缺点。可以通过将化疗药物封装在合适的载体中进行靶向传递来克服这一问题，从而仅在癌症部位释放药物。本文旨在回顾利用纳米技术为口腔恶性肿瘤治疗开发的最新科学进展，从而进一步改善临床实践。我们在PubMed、Google Scholar、ScienceDirect以及其他知名数据库上进行了广泛的文献搜索，以找到与纳米平台及其在口腔癌治疗中的应用相关的最新同行评审的临床试验、综述和研究文章。 纳米平台为克服传统口腔癌治疗所面临的挑战，如药物溶解性差、非特异性靶向和系统毒性，提供了一种革命性的策略。这些纳米尺度的药物传递系统包括脂质体、聚合物纳米颗粒、树状聚合物和水凝胶等多种制剂，可实现治疗剂的控制释放和靶向传递到口腔癌部位。通过利用增强的渗透和滞留效应，纳米平台优先积累于肿瘤微环境中，增加药物浓度并减少对健康组织的损伤。此外，可以通过工程化的方式将纳米平台设计成携带多种药物或药物与诊断剂的组合，实现个体化和精确的治疗方法。 在口腔癌治疗中利用纳米平台具有显著的潜力来革新治疗策略。尽管临床前研究取得了有希望的结果，但还需要进一步研究来评估纳米制剂在临床环境中的安全性、有效性和长期影响。如果成功应用于临床实践，基于纳米平台的治疗方法有可能改善患者预后，减少副作用，并为口腔癌治疗开辟更个体化和有效的途径。 © 2023 The Authors. 由Wiley Periodicals LLC发表的Health Science Reports。

Cytotoxicity is a key disadvantage of using chemotherapeutic drugs to treat cancer. This can be overcome by encapsulating chemotherapeutic drugs in suitable carriers for targeted delivery, allowing them to be released only at the cancerous sites. Herein, we aim to review the recent scientific developments in the utilization of nanotechnology-based drug delivery systems for treating oral malignancies that can lead to further improvements in clinical practice.A comprehensive literature search was conducted on PubMed, Google Scholar, ScienceDirect, and other notable databases to identify recent peer-reviewed clinical trials, reviews, and research articles related to nanoplatforms and their applications in oral cancer treatment.Nanoplatforms offer a revolutionary strategy to overcome the challenges associated with conventional oral cancer treatments, such as poor drug solubility, non-specific targeting, and systemic toxicity. These nanoscale drug delivery systems encompass various formulations, including liposomes, polymeric nanoparticles, dendrimers, and hydrogels, which facilitate controlled release and targeted delivery of therapeutic agents to oral cancer sites. By exploiting the enhanced permeability and retention effect, Nanoplatforms accumulate preferentially in the tumor microenvironment, increasing drug concentration and minimizing damage to healthy tissues. Additionally, nanoplatforms can be engineered to carry multiple drugs or a combination of drugs and diagnostic agents, enabling personalized and precise treatment approaches.The utilization of nanoplatforms in oral cancer treatment holds significant promise in revolutionizing therapeutic strategies. Despite the promising results in preclinical studies, further research is required to evaluate the safety, efficacy, and long-term effects of nanoformulations in clinical settings. If successfully translated into clinical practice, nanoplatform-based therapies have the potential to improve patient outcomes, reduce side effects, and pave the way for more personalized and effective oral cancer treatments.© 2023 The Authors. Health Science Reports published by Wiley Periodicals LLC.