背景：食道癌是世界上癌症死亡的主要原因之一。伊朗北部的戈勒斯坦省是世界上食道癌发病率最高的地区。戈勒斯坦省的北部和南部可以被划分为食道癌的低风险区和高风险区。此人群中食道癌的潜在风险因素之一是营养不良的饮食。膳食抗氧化剂化合物如硒、维生素E、维生素A和β-胡萝卜素是活性氧自由基的清除剂，对细胞应对氧化应激和预防DNA损伤起关键作用。本研究旨在比较高风险区和低风险区健康个体血清中硒、维生素E和维生素A的水平。 方法：本研究包括242名健康个体。用原子吸收分光光度法评估血清中的硒水平，用反相高效液相色谱法评估维生素E和维生素A的水平。 结果：高风险区健康个体的维生素E水平显著低于低风险区，而高风险区和低风险区健康个体的硒和维生素A水平之间没有显著差异。此外，在戈勒斯坦省的城市和农村地区、男性和女性中，硒、维生素E和维生素A的水平也没有显著差异。 结论：在戈勒斯坦省高风险区，高水平的硒与较低水平的维生素E，连同其他风险因素，可能与食道鳞状细胞癌相关。 © 2022《中东消化疾病杂志》

Background: Esophageal cancer is one of the main causes of cancer mortality in the world. Golestan province, in the northern part of Iran, has the highest esophageal cancer rate in the world. The north and south districts of Golestan province can be classified as low and high-risk areas for esophageal cancer. One of the potential risk factors for esophageal cancer in this population is a nutrient-deficient diet. Dietary antioxidant compounds such as selenium, vitamin E, vitamin A, and β-carotene are reactive oxygen species (ROC) scavengers that play a key role in cellular responses to oxidative stress and preventing DNA damage. This study aims to compare the serum levels of selenium, vitamin E, and vitamin A in healthy individuals in high and low-risk areas of esophageal cancer. Methods: This study is a population of 242 healthy individuals. Serum selenium levels were assessed by atomic absorption spectroscopy. Vitamin E and A were assessed by reversed-phase high-performance liquid chromatography. Results: Vitamin E levels of healthy individuals in high-risk areas were significantly lower than in low-risk areas, while there was no significant difference between the selenium and vitamin A levels of healthy individuals in high-risk areas and low-risk areas. Also, there was no significant difference between selenium, vitamin E, and vitamin A levels in urban and rural areas and men and women in Golestan province. Conclusion: High levels of selenium with lower levels of vitamin E, along with other risk factors, may be associated with esophageal squamous cell carcinoma in high-risk areas of Golestan province.© 2022 Middle East Journal of Digestive Diseases.