白细胞介素在哮喘的病理生理过程中起到非常重要的作用。白细胞介素-33（IL-33）是哮喘中部分研究的细胞因子。它与特定的受体抑癌性调节因子2（ST2）结合。本研究旨在评估哮喘患者和健康对照组的IL-33、sST2和IgE血清水平，并进一步研究其与一秒钟用力呼气容积（FEV 1%）和绝对嗜酸性粒细胞计数的相关性。我们招募了100名哮喘患者和57名健康受试者参与本研究。我们测量了血清中IgE、IL-33和sST2的水平。根据血清IgE水平，将患者分为过敏和非过敏组。使用Graph pad prism软件8进行统计分析。我们发现哮喘患者IL-33和IgE水平明显升高，而sST2水平显著低于健康受试者。未控制的哮喘患者FEV1%值降低。此外，血清IL-33水平与IgE显著相关。此外，我们发现过敏哮喘患者IL-33与AEC之间存在显著相关性。在本研究中，我们报告了哮喘患者比健康对照组IL-33和IgE水平升高以及sST2水平降低。IL-33和sST2可能作为哮喘等过敏性疾病的炎症生物标志物。

Interleukins play a very important role in the pathophysiology of asthma. Interleukin-33 (IL-33) is a partially explored cytokine in asthma. It binds with a specific receptor called suppression of tumorigenicity 2 (ST2). The study aims to evaluate the serum levels of IL-33, sST2 and IgE in asthmatic patients and healthy controls and its further association with the forced expiratory volume in one second (FEV 1%) and absolute eosinophil count.We enrolled 100 asthmatic patients and 57 healthy subjects for the study. We measured serum levels of IgE, IL-33, and sST2. Based on serum IgE levels, patients were divided into allergic and non-allergic groups. Statistical analysis was done by using Graph pad prism software 8.We found significantly elevated levels of IL-33 and IgE in asthmatic patients as compared to healthy subjects. However, sST2 levels were significantly lower in asthmatic patients than in healthy subjects. FEV1% values were decreased in uncontrolled asthmatic patients. In addition, serum levels of IL-33 were significantly correlated with the IgE. Furthermore, we found a significant correlation between IL-33 and AEC in allergic asthmatic patients.In this study, we reported elevated IL-33 and IgE levels and decreased sST2 levels in asthmatic patients compared to healthy controls. IL-33 and sST2 may act as inflammatory biomarkers for allergic diseases such as asthma.