N6-甲基腺苷（m6A）RNA修饰近年来成为正常和恶性造血的重要调节因子。作为一种可逆的表观遗传修饰，在信使RNA和非编码RNA中发现的m6A影响修饰的RNA分子的命运。它在多个重要的生物过程中起着至关重要的作用，并促进了癌症的发展。本文综述了m6A修饰在正常造血、白血病发病机制和药物反应/耐药性方面的病理功能和潜在的分子机制的最新研究成果。最后，我们讨论了m6A在免疫应答中的关键作用、靶向m6A调节因子的治疗潜力以及AML的可能联合治疗方案。© 2023. 作者授予 Springer-Verlag GmbH Germany 独家许可，该公司是 Springer Nature 的一部分。

N6-methyladenosine (m6A) RNA modification has recently emerged as an essential regulator of normal and malignant hematopoiesis. As a reversible epigenetic modification found in messenger RNAs and non-coding RNAs, m6A affects the fate of the modified RNA molecules. It is essential in most vital bioprocesses, contributing to cancer development. Here, we review the up-to-date knowledge of the pathological functions and underlying molecular mechanism of m6A modifications in normal hematopoiesis, leukemia pathogenesis, and drug response/resistance. At last, we discuss the critical role of m6A in immune response, the therapeutic potential of targeting m6A regulators, and the possible combination therapy for AML.© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.