研究动态
Articles below are published ahead of final publication in an issue. Please cite articles in the following format: authors, (year), title, journal, DOI.

口腔癌患者长期咽喉功能和影响吞咽功能障碍及生活质量的因素:一项前瞻性观察研究。

Long-term swallow outcomes and factors affecting swallowing dysfunction and quality of life among oral cancer patients: a prospective observational study.

发表日期:2023 Aug 07
作者: Abhinav Thaduri, Sravani Reddy Kappari, Kinjal Shankar Majumdar, Achyuth Panuganti, Shahab Ali Usmani, Vikramjit Singh, Areej Moideen, Manu Malhotra, Pankaj Kumar Garg
来源: Food & Function

摘要:

口腔癌是印度人口中最常见的癌症之一。印度是全球口腔癌的主要负担国。治疗口腔癌后常见吞咽功能障碍。接受口腔癌切除手术的患者的吞咽过程常常会受到干扰。本研究的主要目的是使用患者报告的结果问卷评估口腔癌患者的长期吞咽结果。选取了2020年3月到2022年3月期间在我们医院接受即刻手术和重建的连续患者,其cT2-T4级别。悉尼吞咽问卷(SSQ)和功能性口进食量表(FOIS)评估了治疗结束后六个月的吞咽结果。世界卫生组织生活质量问卷(WHO BREF)用于评估与健康相关的生活质量。总计包括了七十例口腔癌患者。年龄中位数为49岁。其中大部分是男性(90%)。cT4级别肿瘤占62%,剩余的48%是cT2和cT3级别。其中大多数是颧上颌部位的肿瘤(64.3%)。近三分之二的患者接受了多模式治疗。咀嚼困难和口干症分别达到了46%和88%。平均SSQ得分为257.4 ± 99.1。吞咽结果受T分期(p = 0.01)、切除范围(p = 0.01)、多模式治疗(p < 0.01)、咀嚼困难(p = 0.05)和口干症(p = 0.01)的影响。近69%的患者需要特别的食物准备来进行吞咽(FOIS 4&5级)。颧上颌病变的患者(p = 0.05)的生活质量明显较差。晚期疾病、广泛切除和接受多模式治疗会导致吞咽结果不佳。治疗后的咀嚼困难和口干症也明显影响吞咽结果。© 2023. 作者或作者团队独家许可给Springer-Verlag GmbH Germany, Springer Nature的一部分。
Oral cancer is one of the most common cancers among the Indian population. India bears the most burden of oral cancer globally. Impairment of swallowing function is often seen after treatment for oral cancer. The oral phase of swallowing is disrupted in patients undergoing resection for oral cancer. The primary purpose of this study was to evaluate the long-term swallowing outcomes of oral cancer patients using a patient-reported outcome questionnaire.All consecutive oral cancer patients in the cT2-T4 category undergoing curative-intent surgery and reconstruction at our institute from March 2020 to March 2022 were included in the study. The Sydney Swallow questionnaire (SSQ) and functional oral intake scale (FOIS) assessed swallowing outcomes six months after definitive treatment. WHO BREF quality-of-life questionnaire was used to assess health-related quality of life.A total of seventy patients with oral cancer were included. The median age was 49 years. The majority of them were males (90%). Tumors with cT4 constituted 62%; the rest, 48%, were cT2 and cT3 categories. The bulk of them were buccoalveolar tumors (64.3%. Almost two-thirds of the patients received multimodal treatment. Trismus and xerostomia were at 46% and 88%, respectively. The mean SSQ score was 257.4 ± 99.1. Swallowing outcomes are affected by T stage (p = 0.01), extent of resection (p = 0.01), multimodality treatment (p < 0.01), trismus (p = 0.05), and xerostomia (p = 0.01). Almost 69% of them required special food preparation for swallowing (FOIS 4&5). Patients with buccoalveolar disease (p = 0.05) had significantly poor quality of life.An advanced stage with extensive resection and receiving multimodal treatment has adverse swallowing outcomes. Post-treatment trismus and xerostomia also significantly affected swallowing results.© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.