髓母细胞瘤（MB）是儿童最常见的恶性脑肿瘤。社会经济地位（SES）与髓母细胞瘤的存活结果之间的关联仍不清楚。本研究旨在开发一个预测髓母细胞瘤特异死亡（MBSD）和总生存（OS）的 nomogram ，考虑到髓母细胞瘤患者的社会经济因素。我们从监测、流行病学和结果数据库中纳入了1975年至2016年间被诊断为 MB 的患者。进行倾向性分数匹配（PSM）以减少选择偏差。使用多变量 Cox 比例风险模型评估社会经济地位对髓母细胞瘤特异死亡和总生存的影响，以及临床相关变量。通过多变量分析确定的独立预后因素用于构建 nomogram 。匹配后共纳入2660名患者。研究发现，失业率（MBSD，高水平 vs. 低水平，P = 0.020）（OS，高水平 vs. 低水平，P = 0.017），以及婚姻状况（OS，已婚 vs. 未婚/未知，P = 0.029）是影响男性髓母细胞瘤预后的重要因素。同时，家庭收入中位数（MBSD，第一四分位 vs. 第三四分位，P = 0.047）（OS，第一四分位 vs. 第二四分位，P = 0.017）（OS，第一四分位 vs. 第三四分位，P = 0.014），居住地（MBSD，城市 vs. 农村，P = 0.041），以及保险状况（MBSD，已投保 vs. 未投保/未知，P = 0.002）（OS，已投保 vs. 未投保/未知，P = 0.001）是影响女性髓母细胞瘤预后的重要因素。通过校准图和 C-指数测试，我们的 nomogram 也具有预测意义。MB的独特特征为分析种族、民族、性别和社会经济因素的影响提供了一个场景。当前的研究结果对实现健康人口的目标具有重要的公共卫生意义。鉴于已知的发病率、这些儿童及其家庭必须承受的长期心理、经济和医疗负担，识别和解决这些差距至关重要。© 2023年。W·蒙塔古·科布-全美医师协会卫生研究所。

Medulloblastoma (MB) is the most common malignant brain tumor of childhood. The associations between socioeconomic statuses (SES) and survival outcomes of medulloblastoma remain unclear. The aim of this study was to develop a nomogram to predict medulloblastoma specific death (MBSD) and overall survival (OS) in patients with medulloblastoma, taking into account socioeconomic factors in patients with medulloblastoma.We included patients diagnosed with MB between 1975 and 2016 from the Surveillance, Epidemiology, and End Results database. Propensity Score Matching (PSM) was performed to reduce selection bias. Multivariate cox proportional hazards model was used to assess SES impact and clinically relevant variables of medulloblastoma specific death and overall survival. Independent prognostic factors determined by multivariate analysis were used to construct nomograms.A total of 2660 patients were enrolled after matching. Study showed unemployed rate (MBSD, high level vs. low level, P = 0.020) (OS, high level vs. low level, P = 0.017), and marital status (OS, married vs unmarried/unknown, P = 0.029) were important factors affecting prognosis of medulloblastoma in male. Meanwhile, median household income (MBSD, quartile 1 vs. quartile 3, P = 0.047) (OS, quartile 1 vs. quartile 2, P = 0.017) (OS, quartile 1 vs. quartile 3, P = 0.014), residence (MBSD, urban vs. rural, P = 0.041), and insurance status (MBSD, insured vs. uninsured/unknown, P = 0.002)(OS, insured vs. uninsured/unknown, P = 0.001) were significant factors affecting prognosis of medulloblastoma in female. Through the calibration plot and C-index test, our nomogram was also of predictive significance.The unique features of MB have provided a scenario for analysis of the impact of racial, ethnic, gender, and socioeconomic factors. The current findings have important public health implications for achieving the goal of a healthy population. Given the known morbidity rates, long-term psychological, financial and medical burdens that these children and their families must bear, it is critical to identify and address these gaps.© 2023. W. Montague Cobb-NMA Health Institute.