卵巢癌，更确切地说，高级别浆液性卵巢癌，是全球妇女中一种最致命的与年龄无关的妇科恶性肿瘤之一。有越来越多的证据表明端粒与RIF1蛋白以及癌细胞增殖之间存在联系。端粒是染色体顶端的六聚体（TTAGGG）串联重复序列，随着体细胞的分裂而缩短，限制细胞增殖并作为预防癌症的重要屏障。RIF1（复制时调节因子1）在调节端粒长度等因素中扮演重要角色。有趣的是，RIF1似乎影响DNA双链断裂（DSB）修复途径。然而，关于RIF1与端粒之间相互作用及其在上皮性卵巢癌（EOC）发展中的程度的详细知识仍然尚不清楚，尽管这样的知识可能与临床实践中找到新的生物标志物相关。在这份综述中，我们提供最新文献的更新，以阐明卵巢癌发展中端粒生物学与RIF1蛋白之间的关系。

Ovarian cancer, more precisely high-grade serous ovarian cancer, is one of the most lethal ageindependent gynecologic malignancies in women worldwide, regardless of age. There is mounting evidence that there is a link between telomeres and the RIF1 protein and the proliferation of cancer cells. Telomeres are hexameric (TTAGGG) tandem repeats at the tip of chromosomes that shorten as somatic cells divide, limiting cell proliferation and serving as an important barrier in preventing cancer. RIF1 (Replication Time Regulation Factor 1) plays, among other factors, an important role in the regulation of telomere length. Interestingly, RIF1 appears to influence the DNA double-strand break (DSB) repair pathway. However, detailed knowledge regarding the interplay between RIF1 and telomeres and their degree of engagement in epithelial ovarian cancer (EOC) is still elusive, despite the fact that such knowledge could be of relevance in clinical practice to find novel biomarkers. In this review, we provide an update of recent literature to elucidate the relation between telomere biology and the RIF1 protein during the development of ovarian cancer in women.