肿瘤不断与其微环境进行相互作用。在这里，我们提供了关于果蝇中Notch诱导的神经干细胞（NSC）肿瘤的数据，该肿瘤可以通过在成年宿主中进行序列移植而不老化。这种肿瘤是通过Notch在NSC后代中抑制早期分化促进因子的能力而在幼虫中产生的。根据转录组数据的指导，我们已经研究了肿瘤内在因素和微环境特异性因素，并探讨了它们如何对肿瘤生长和宿主死亡的影响。肿瘤细胞中的生长促进因子Myc、Imp和胰岛素受体在肿瘤扩张和宿主死亡中起到重要作用。从宿主的角度来看，与肿瘤细胞有关的血细胞专业吞噬细胞——血红细胞。吞噬性受体，例如NimC1，需要在血细胞中才能使其能够捕获和吞噬肿瘤细胞，限制其生长。除了其保护作用外，血细胞还可能通过产生有害的细胞外活性氧物质来增加宿主发病率。

Tumors constantly interact with their microenvironment. Here, we present data on a Notch-induced neural stem cell (NSC) tumor in Drosophila, which can be immortalized by serial transplantation in adult hosts. This tumor arises in the larva by virtue of the ability of Notch to suppress early differentiation-promoting factors in NSC progeny. Guided by transcriptome data, we have addressed both tumor-intrinsic and microenvironment-specific factors and how they contribute to tumor growth and host demise. The growth promoting factors Myc, Imp, and Insulin receptor in the tumor cells are important for tumor expansion and killing of the host. From the host's side, hemocytes, professional phagocytic blood cells, are found associated with tumor cells. Phagocytic receptors, like NimC1, are needed in hemocytes to enable them to capture and engulf tumor cells, restricting their growth. In addition to their protective role, hemocytes may also increase the host's morbidity by their propensity to produce damaging extracellular reactive oxygen species.