本研究旨在确定癌胚抗原-125（CA-125）与血清人绒毛膜促性腺激素（β-hCG）和孕酮结合在早期诊断异位妊娠（EP）中的预测价值。在2019年5月至2020年5月期间，我们进行了一项横断面研究，招募了42例EP病例和42例同一孕周的正常妊娠（IUP）病例，他们在访问医药大学费洪宫妇产科时就诊。EP的诊断基于手术（腹腔镜）和术后病理检查。EP组和IUP组的β-hCG（2570 mUI/mL vs. 18357.7 mUI/mL）、孕酮（10.79 ± 8.16 ng/ml vs. 27.42 ± 4.17 ng/ml）和CA-125（26.90 ± 10.26 U/mL vs. 70.61 ± 20.89 U/mL）的平均水平存在显著差异（p < 0.001）。在早期诊断EP的预测中，CA-125在30.94 U/mL处的临界值具有89.3%的敏感性和87.9%的特异性；β-hCG在2750mIU/ml处的临界值具有75%的敏感性和78.8%的特异性；孕酮在10.24 ng/mL处的临界值具有85.7%的敏感性和81.8%的特异性。CA-125、β-hCG和孕酮的组合在早期诊断EP中具有92.8%的敏感性和90.9%的特异性。血清CA-125水平可以独立使用，也可与其他指标结合在早期诊断EP中。版权所有©2023 Elsevier Ltd.保留所有权利。

This study aimed to determine the predictive value of cancer antigen-125 (CA-125) in combination with serum beta-human chorionic gonadotropin (β-hCG) and progesterone in the early detection of ectopic pregnancy (EP).Between May 2019 and May 2020, the cross-sectional study recruited 42 cases of EP and 42 cases of IUP at the same gestational age who visited the Department of Obstetrics and Gynecology, Hospital of Hue University of Medicine and Pharmacy. EP was diagnosed based on surgical (laparoscopy) and postoperative pathology examination.There were significant differences of mean level of β-hCG (2570 mUI/mL vs. 18357.7 mUI/mL), progesterone (10.79 ± 8.16 ng/ml vs. 27.42 ± 4.17 ng/ml) and CA-125 (26.90 ± 10.26 U/mL vs. 70.61 ± 20.89 U/mL) between the EP and the IUP groups (p < 0.001). In the prediction of early diagnosis of EP, the cut-off value of CA-125 at 30.94 U/mL has a sensitivity of 89.3% and a specificity of 87,9%; the cut-off value of β hCG at 2750mIU/ml has the sensitivity of 75%, specificity of 78,8%; the cut-off value of progesterone at 10.24 ng/mL has the sensitivity of 85.7%, specificity of 81.8%. A combination of CA-125, β hCG, and progesterone had a sensitivity of 92.8% and a specificity of 90.9% in early diagnosis of EP.Serum CA-125 levels can be used independently or in combination with other markers in the early diagnosis of EP.Copyright © 2023 Elsevier Ltd. All rights reserved.