肾上腺解剖性血管瘤:七例临床病理系列研究
Anastomosing haemangioma of the adrenal gland: A clinicopathological series of seven cases.
发表日期:2023 Aug 08
作者:
Reza Alaghehbandan, Erick M Remer, Eren Berber, Jesse K McKenney
来源:
HISTOPATHOLOGY
摘要:
已经报道过动态网教育基的血管瘤是一种罕见的良性血管肿瘤,可以在组织学上模仿血管肉瘤。我们报告了肾上腺中动脉吻合型血管瘤的最大单一机构系列,重点关注其临床和放射学特征。我们的实验室信息系统从1999年至2023年的25年期间进行了搜索,得到了7例被病理学重新评估确认为肾上腺中动脉吻合型血管瘤的病例。临床、放射学和病理学信息来自医疗记录和提交的病理学家。总共有七位患者,其中男性四例(57.1%),女性三例,年龄介于37岁到75岁之间(平均值为61岁)。七位患者中,有六位接受了肾上腺切除术,一位进行了根治性肾切除术。肿瘤大小从0.7厘米到6.4厘米不等(平均为2.1厘米),其中五个肿瘤(71%)明显为良性肿块。其中五个病变是在为其他指征进行的影像学检查中无意中发现的。在接受对比增强影像检查的五个肿瘤中,有三个几乎完全呈高密度增强,中央有一个非增强的小部分,这些特征与嗜铬细胞瘤相重叠。其中一个肿瘤涉及到周围脂肪组织,表现为局部浸润性生长模式。在六位有可用随访数据的患者中,没有发生复发或转移(中位随访时间为95个月)。肾上腺的良性中动脉吻合型血管瘤倾向于发生在年长患者身上,在影像学上可能模仿嗜铬细胞瘤,需要通过病理学方法加以区分。病理学家、放射科医生和外科医生对此疾病的更好了解对于适当的检查、诊断和治疗至关重要。
Anastomosing haemangioma is a rare benign vascular neoplasm that may histologically mimic angiosarcoma. We report the largest single institution series of anastomosing haemangioma in the adrenal gland with emphasis on clinical and radiological features.Our laboratory information system was searched for a 25-year period (1999-2023), yielding seven cases confirmed as anastomosing haemangioma of the adrenal gland after pathological re-review. Clinical, radiological and pathological information was obtained from medical charts and submitting pathologists. Of a total of seven patients, four (57.1%) were men and three women, ranging in age from 37 to 75 years (mean = 61). Six of seven patients underwent adrenalectomies and one had radical nephrectomy. Tumours ranged from 0.7 to 6.4 cm (mean = 2.1 cm) and five of seven (71%) were grossly well-circumscribed. Five of seven lesions were found incidentally at imaging for other indications. All tumours were unifocal except one, which presented with multifocal disease with a concurrent adjacent retroperitoneal anastomosing haemangioma. Three of five tumours imaged with contrast enhancement were almost completely hyperenhancing with a small central non-enhancing portion, features overlapping with pheochromocytoma. One of seven tumours involved the peri-adrenal adipose tissue with a focally infiltrative pattern. There were no recurrences or metastases in six patients with available follow-up data (median = 95 months).Benign anastomosing haemangiomas of the adrenal gland tend to occur in older patients, may mimic pheochromocytoma on imaging and must be distinguished from angiosarcoma pathologically. Better awareness of this entity by pathologists, radiologists and surgeons is crucial to appropriate work-up, diagnosis and management.© 2023 The Authors. Histopathology published by John Wiley & Sons Ltd.