锻炼作为免疫增强剂：对生活方式干预的机制驱动支持。
Exercise as an Immune Boost: Mechanism-Driven Support for Lifestyle Interventions.
发表日期：2023 Sep 01
作者：
Allison Betof Warner
来源：
Cancer Immunology Research
摘要：
可修饰的宿主因子已被证明有望增强免疫治疗的反应。在本期中，Savage 等人。研究了使用有氧运动来增强黑色素瘤小鼠模型的抗肿瘤免疫力。他们表明，跑步机跑步可以改善肿瘤脉管系统，并通过 ERK5 依赖性机制改变肿瘤的 T 细胞和骨髓细胞浸润，这为支持运动的免疫介导抗肿瘤作用提供了越来越多的证据。参见 Savage 等人的相关文章，第 17 页。 1168 (3).©2023 美国癌症研究协会。
Modifiable host factors have demonstrated promise to enhance responses to immunotherapy. In this issue, Savage et al. investigated the use of aerobic exercise to enhance antitumor immunity in a murine model of melanoma. They show that treadmill running improves tumor vasculature and alters both T-cell and myeloid-cell infiltration of the tumor via an ERK5-dependent mechanism, adding to the growing evidence supporting the immune-mediated antitumor effects of exercise. See related article by Savage et al., p. 1168 (3).©2023 American Association for Cancer Research.