自噬是一个保持细胞和有机体内稳态的必要回收和质量控制途径。作为一个分解代谢过程，自噬会在应激条件下，如营养匮乏、氧化和基因毒性应激中降解受损和老化的细胞内成分。自噬是一个高度适应性和动态的过程，需要复杂协调的分子控制。在这里，我们对自噬是如何通过转录后调控，即RNA加工事件、表观转录后修饰和非编码RNA进行调控进行概述。我们进一步讨论了核心自噬机制蛋白的新发现的RNA结合特性，并回顾了自噬对细胞RNA稳态影响的最新迹象。从生理学角度出发，我们研究了这些新出现的自噬调控层面对于营养匮乏和肿瘤发生的生物学意义。© 2023.作者，ADMCAssociazione Differenziamento e Morte Cellulare的独家许可证下。

Autophagy is an essential recycling and quality control pathway which preserves cellular and organismal homeostasis. As a catabolic process, autophagy degrades damaged and aged intracellular components in response to conditions of stress, including nutrient deprivation, oxidative and genotoxic stress. Autophagy is a highly adaptive and dynamic process which requires an intricately coordinated molecular control. Here we provide an overview of how autophagy is regulated post-transcriptionally, through RNA processing events, epitranscriptomic modifications and non-coding RNAs. We further discuss newly revealed RNA-binding properties of core autophagy machinery proteins and review recent indications of autophagy's ability to impact cellular RNA homeostasis. From a physiological perspective, we examine the biological implications of these emerging regulatory layers of autophagy, particularly in the context of nutrient deprivation and tumorigenesis.© 2023. The Author(s), under exclusive licence to ADMC Associazione Differenziamento e Morte Cellulare.