可逆的氧化-还原稳态机制作为一种特异的信号转导系统发挥作用，引发相关的生理反应。氧化还原稳态的紊乱可能会产生负面后果，包括潜在的癌症发展和进展，这与一系列氧化还原过程密切相关，如调节活性氧化物（ROS）水平和种类，改变抗氧化能力，以及ROS对下游细胞命运和免疫力的差异性影响。肿瘤微环境（TME）在免疫力和调控性细胞死亡之间展示复杂的相互作用，尤其是自噬和凋亡，这在很大程度上受ROS的调控。本研究旨在探讨多源ROS如何影响TME中的凋亡、自噬和抗肿瘤免疫应答的机制，以及这三个过程之间的相互交流。鉴于ROS在控制细胞命运和免疫力方面的复杂作用，我们还将进一步研究传统癌症治疗与ROS之间的关系。值得注意的是，我们将讨论一些与ROS相关的潜在治疗选择以供将来的研究进一步探讨。© 2023年。BioMed Central有限公司，Springer Nature的一部分。

The reversible oxidation-reduction homeostasis mechanism functions as a specific signal transduction system, eliciting related physiological responses. Disruptions to redox homeostasis can have negative consequences, including the potential for cancer development and progression, which are closely linked to a series of redox processes, such as adjustment of reactive oxygen species (ROS) levels and species, changes in antioxidant capacity, and differential effects of ROS on downstream cell fate and immune capacity. The tumor microenvironment (TME) exhibits a complex interplay between immunity and regulatory cell death, especially autophagy and apoptosis, which is crucially regulated by ROS. The present study aims to investigate the mechanism by which multi-source ROS affects apoptosis, autophagy, and the anti-tumor immune response in the TME and the mutual crosstalk between these three processes. Given the intricate role of ROS in controlling cell fate and immunity, we will further examine the relationship between traditional cancer therapy and ROS. It is worth noting that we will discuss some potential ROS-related treatment options for further future studies.© 2023. BioMed Central Ltd., part of Springer Nature.