背景：结肠腺癌（COAD）是一种常见的恶性肿瘤，具有高发病率和死亡率。免疫系统在结直肠癌（CRC）的发展和进展中起到关键作用，因此可能成为治疗的潜在靶点。本研究通过分析CRC患者的转录组数据，研究免疫浸润情况并鉴定潜在治疗靶点。方法和结果：我们使用CIBERSORT分析COAD样本中的免疫浸润情况，并发现M2巨噬细胞和中性粒细胞的高浸润与预后不良相关。接下来，基于两个预测模型中NR4A1的保护作用，我们将其确定为潜在治疗靶点。使用癌症治疗反应分析，我们发现NR4A1的高表达水平对OSI-930（一种抗肿瘤效果的酪氨酸激酶抑制剂）敏感。结论：我们的研究结果显示，用OSI-930靶向NR4A1可能成为COAD患者高程度免疫浸润的一种有前景的治疗策略。然而，需要进一步研究来研究该方法的临床疗效。Copyright © 2023 李、张、李、陈、唐、程。

Background: Colon adenocarcinoma (COAD) is a common malignancy with high morbidity and mortality rates. The immune system plays a crucial role in CRC development and progression, making it a potential therapeutic target. In this study, we analyzed transcriptomic data from CRC patients to investigate immune infiltration and identify potential therapeutic targets. Method and results: we used CIBERSORT to analyze the immune infiltration in COAD samples and found that the high infiltration of M2 macrophages and neutrophils was associated with poor prognosis. Next, we identified NR4A1 as a potential therapeutic target based on its protective effect in two predict models. Using cancer therapeutics response analysis, we found that high expression levels of NR4A1 were sensitive to OSI-930, a tyrosine kinase inhibitor with anti-tumor effects. Conclusion: Our findings suggest that targeting NR4A1 with OSI-930 may be a promising therapeutic strategy for COAD patients with high levels of immune infiltration. However, further studies are needed to investigate the clinical efficacy of this approach.Copyright © 2023 Li, Zhang, Li, Chen, Tang and Cheng.