成人T细胞白血病/淋巴瘤是一种由HTLV-1感染引起的预后不良的恶性肿瘤。TAX和HBZ是两个重要的病毒蛋白，可能通过干扰细胞凋亡来参与肿瘤发生。由于Bcl-xL在抗凋亡通路中起着关键作用，本研究考察了宿主细胞凋亡与癌基因蛋白之间的相互作用。我们调查了37例HTLV-1感染者，包括18例无症状和19例ATLL患者。我们从外周血单个核细胞（PBMCs）中提取并转化mRNA为cDNA，然后使用TaqMan qPCR确定基因表达。此外，还使用商业绝对定量试剂盒（Novin Gene，伊朗）测量HTLV-I的基因负荷。数据分析显示，ATLL组和携带者组的TAX、HBZ和PVL的平均值显著高于对照组（P=（0.003）、P=（0.000）和P=（0.002））。研究组之间Bcl-xL基因表达无统计学差异（P=0.323）。因此，提出抗凋亡通路可能与ATLL淋巴瘤的发展无直接关系，TAX、HBZ基因表达和PVL可作为预后标志物。

Adult T-cell leukemia/lymphoma is a malignancy with a poor prognosis caused by HTLV-1 infection. TAX and HBZ are two major viral proteins that may be involved in oncogenesis by disrupting apoptosis. Because Bcl-xL plays an integral role in the anti-apoptotic pathway, this study examines the interaction between host apoptosis and oncoproteins.We investigated 37 HTLV-1-infected individuals, including 18 asymptomatic and 19 ATLL subjects. mRNA was extracted and converted to cDNA from peripheral blood mononuclear cells (PBMCs), and then gene expression was determined using TaqMan qPCR. Moreover, the HTLV-I proviral load was also measured using a commercial absolute quantification kit (Novin Gene, Iran).Data analysis revealed that the mean of TAX, HBZ, and PVL was significantly higher among the study groups (ATLL and carriers groups P= (0.003), P= (0.000), and P= (0.002) respectively). There was no statistical difference in Bcl-xL gene expression between studies groups (P=0.323).It is proposed that this anti-apoptotic pathway may not be directly involved in the development of ATLL lymphoma. TAX, HBZ gene expression, and PVL can be utilized as prognostic markers.