早期诊断是提高肺癌患者存活率的关键因素，因此开发一种简单快速的癌症检测方法至关重要。在多种诊断方法中，电化学传感器由于其出色的性能、便携性、实时分析、稳固性、易操作性和经济性而成为最有前途的方法。导电高分子复合材料已经被广泛用于制备稳固的传感器设备，因为它们具有出色的物理和电化学性质，并且对生物系统具有良好的生物相容性并且没有毒性影响。本综述简要概述了电化学生物传感器在肺癌早期检测中的重要性，并详细讨论了用于生物传感器应用的导电高分子复合材料的设计和开发。本综述涵盖了基于导电聚硫噻吩、聚(3,4-乙二氧基噻吩)、聚苯胺、聚吡咯、分子印迹聚合物等复合电极的多种肺癌标志物的电化学检测。此外，还强调了电化学生物传感器与其他技术的混合应用。对于基于导电高分子复合材料的电化学生物传感器用于便携式诊断设备的发展前景也进行了简要讨论。版权所有 © 2023. Elsevier B.V.出版。

The development of a simple and fast cancer detection method is crucial since early diagnosis is a key factor in increasing survival rates for lung cancer patients. Among several diagnosis methods, the electrochemical sensor is the most promising one due to its outstanding performance, portability, real-time analysis, robustness, amenability, and cost-effectiveness. Conducting polymer (CP) composites have been frequently used to fabricate a robust sensor device, owing to their excellent physical and electrochemical properties as well as biocompatibility with nontoxic effects on the biological system. This review brings up a brief overview of the importance of electrochemical biosensors for the early detection of lung cancer, with a detailed discussion on the design and development of CP composite materials for biosensor applications. The review covers the electrochemical sensing of numerous lung cancer markers employing composite electrodes based on the conducting polyterthiophene, poly(3,4-ethylenedioxythiophene), polyaniline, polypyrrole, molecularly imprinted polymers, and others. In addition, a hybrid of the electrochemical biosensors and other techniques was highlighted. The outlook was also briefly discussed for the development of CP composite-based electrochemical biosensors for POC diagnostic devices.Copyright © 2023. Published by Elsevier B.V.