根据德国的国家癌症计划，所有癌症患者都应按照循证治疗指南接受高质量的护理。为此设立了认证计划，但尚未全面评估。在由创新基金（项目编号01VSF17020）支持的WiZen项目中，进行了对九种癌症的首次治疗是否在拥有德国癌症学会认证的医院进行与否与整体生存率（主要终点）是否有差异的对照队列研究。这些研究基于2009年至2017年德国法定健康保险机构（AOK）成年被保人的全国数据。除了乳腺癌外，大多数患者的首次治疗都是在非认证医院进行的。经过对患者和医院相关混杂因素进行大量调整后，认证医院的首次治疗在整体生存率方面是有益的。危险比（HR）范围为0.97（95% CI：【0.94；1.00】）（肺癌）到0.77（【0.74；0.81】）（乳腺癌），对应于肺癌0.62个月到宫颈癌4.61个月的绝对风险减少。WiZen研究表明，对于研究的实体，认证中心的癌症初始治疗与更低的死亡率相关。然而，尽管国家癌症计划的建议，仍有超过40％的癌症患者在非认证医院接受初始治疗。有序在认证医院提供初始护理将很可能改善整体生存率。尽管研究设计不能得出因果关系的结论，但考虑到使用了对照组、考虑到混杂因素，并且研究人口规模较大，这些结果似乎是可靠的。

According to the National Cancer Plan in Germany, all cancer patients should receive high-quality care in accordance with evidence-based treatment guidelines. Certification programs were established for this purpose but have not yet been comprehensively evaluated.In the WiZen project, which was supported by the Innovation Fund (supported project number 01VSF17020), controlled cohort studies were performed to investigate whether initial treatment in hospitals with or without a certificate from the German Cancer Society was associated with a difference in overall survival (primary endpoint) in patients with cancer of the colon, rectum, lung, pancreas, breast, cervix, prostate, endometrium, and ovary, head and neck cancer, and neuro-oncological tumors. The studies were based on nationwide data from adult insurees of the AOK statutory health insurance carrier for the years 2009-2017.The majority of patients with all entities except breast cancer received their initial treatment in non-certified hospitals. Initial treatment in a certified hospital was found to be beneficial in terms of overall survival for all cancer entities, even after extensive adjustment for patient- and hospital-related confounders. The hazard ratio (HR) ranged from 0.97 (95% CI: [0.94; 1.00]) for lung cancer to 0.77 [0.74; 0.81] for breast cancer, corresponding to an absolute risk reduction (ARR) for overall survival of 0.62 months for lung cancer to 4.61 months for cervical cancer.The WiZen study shows for the entities studied that initial cancer treatment in a certified center is associated with lower mortality. Despite the recommendations of the National Cancer Plan, however, more than 40% of all cancer patients still receive their initial treatment in a non-certified hospital. The preferential provision of initial care in certified hospitals would be likely to improve overall survival. Although the study design does not permit any conclusion with regard to causality, the findings seem robust considering that a control group was used, confounders were taken into account, and the study population was of large size.