背景：需要进行更多使用钴配合物作为药物的研究。结果：确定了两种钴水杨醛亚胺的药物作用。这些配合物和重阿莫西林（20mg/ml）抑制了白色念珠菌，其抑菌区直径为9-15和21mm。这两种配体的浓度抑制金黄色葡萄球菌的抑菌区直径为10mm，其中一种配体抑制大肠杆菌的抑菌区直径为9mm，而这些配合物和氨苄青霉素抑制了四种细菌，抑菌区直径为9-20和21-26mm。这些配体对癌细胞和正常细胞无活性，但这些配合物和多柔比星对MCF-7细胞提供了IC50值为28.18-54.19μM，对BHK细胞提供了IC50值为15.76-20.49μM和36.42μM。结论：配合物的活性得到了很大的改善，尽管它们仍不达标准。

Background: More studies using cobalt complexes as drugs are needed. Results: The drug action of two cobalt salicylaldimines was determined. The complexes and amphotericin B (20 mg/ml) inhibited Candida albicans at 9-15 and 21 mm. This concentration of both ligands inhibited Staphylococcus aureus at 10 mm and one ligand inhibited Escherichia coli at 9 mm, but the complexes and ampicillin inhibited four bacteria at 9-20 and 21-26 mm. The ligands were inactive against cancer and normal cells, but the complexes and doxorubicin provided IC50 values of 28.18-54.19 and 9.66 μM against MCF-7 cells and 15.76-20.49 and 36.42 μM against BHK cells. Conclusion: The ligands' activity was much improved by complexation, although they remained substandard.