最大的跨膜黏蛋白，黏蛋白16（MUC16），具有分子表面上丰富的糖基化位点，使其能够参与各种分子途径。当细胞失去极性并变为癌性时，MUC16被过度表达，更多的细胞外区域（癌胚抗原[CA]125）被释放到血清中，可能促进疾病的发展。因此，MUC16在临床研究和应用中发挥着不可或缺的作用。本综述总结了在癌变和转移中MUC16的最新提出的作用。最重要的是，我们展望了在PubMed上最近十年发表的1226篇文章中，MUC16在靶向治疗中的潜在价值。两名评审人员独立筛选每个记录和检索到的每个报告。我们总结了MUC16/CA125在基础研究和临床应用中的进展，并预测了其可能的未来发展方向。作为妇科疾病诊断中重要的非侵入性因子，MUC16已经被长期使用，尤其是在卵巢癌的诊断和治疗中。MUC16的过度表达在调节炎症反应、支持免疫抑制以及促进癌细胞的增殖、分裂和转移方面发挥了非常明显的作用。在未来的20年中，作为免疫监测和免疫治疗的靶点，MUC16将有着丰富的临床应用。

The largest transmembrane mucin, mucin 16 (MUC16), contains abundant glycosylation sites on the molecular surface, allowing it to participate in various molecular pathways. When cells lose polarity and become cancerous, MUC16 is overexpressed, and more of the extracellular region (cancer antigen [CA]125) is released into serum and possibly，promote the development of diseases. Thus, MUC16 plays an indispensable role in clinical research and application.This review summarizes the update proposed role of MUC16 in carcinogenesis and metastasis. Most importantly, we prospect its potential value in targeted therapy after screening 1226 articles published within the last ten years from PubMed. Two reviewers screened each record and each report retrieved independently. We have summarized the progress of MUC16/CA125 in basic research and clinical application, and predicted its possible future development directions.As an important noninvasive co-factor in the diagnosis of gynecological diseases, MUC16 has been used for a long time, especially in the diagnosis and treatment of ovarian cancer. The overexpression of MUC16 plays a very obvious role in regulating inflammatory response, supporting immune suppression, and promoting the proliferation, division, and metastasis of cancer cells. In the next 20 years, there will be a luxuriant clinical application of MUC16 as a target for immune monitoring and immunotherapy.