蛋白质的泛素-蛋白酶体降解在维持细胞健康稳态中起着重要的调控机制。泛素-蛋白酶体系统的失调与多种疾病相关，因为它能够控制细胞中蛋白质的丰度和周转。此外，蛋白质周转速率的蛋白酶体调节可以决定细胞对外部刺激的反应。在这方面，Bcl-2蛋白家族是参与细胞应对外部刺激中介细胞存活或细胞死亡的重要蛋白质群。抗凋亡蛋白的异常过表达或凋亡促进蛋白的缺失可能导致癌症的发展。毫不奇怪，Bcl-2蛋白的蛋白酶体降解也是一种重要的调节因素，可用来调控Bcl-2蛋白水平，从而影响细胞凋亡的功能结果。因此，本综述旨在重点强调Bcl-2蛋白家族的调节机制，特别侧重于蛋白酶体介导的降解途径以及针对蛋白酶体系统的治疗方法的当前文献。

Proteasomal degradation of proteins represents an important regulatory mechanism in maintaining healthy homeostasis in cells. Deregulation of the ubiquitin-proteasome system is associated with various diseases as it controls protein abundance and turnover in cells. Furthermore, proteasomal regulation of protein turnover rate can determine the cell's response to external stimuli. To this end, the Bcl-2 family of proteins is an important group of proteins involved in mediating cell survival or cell death in response to external stimuli. Aberrant overexpression of anti-apoptotic proteins or deletion of pro-apoptotic proteins can lead to the development of cancer. Unsurprisingly, proteasomal degradation of Bcl-2 proteins also serves as an important factor to regulating the level of Bcl-2 proteins and thereby affecting the functional outcome of cell death. Thus, this review aims to highlight the regulation of Bcl-2 family of proteins with particular emphasis on the proteasomal-mediated degradation pathways and the current literature on the therapeutic approaches targeting the proteasome system.