在本研究中，采用乙酰化苏打木素（ASL）和非乙酰化苏打木素（SL）分别与PLA按不同浓度共混，制备具有抗氧化性能的聚乳酸（PLA）/木素复合材料，以用于潜在的生物医学应用。对苏打木素乙酰化后的PLA与木素之间进行扫描电子显微镜观察，发现二者具有良好的相容性。所有PLA/ASL复合材料的力学性能均高于PLA/SL复合材料。其中，PLA/ASL5的力学特性最好，其断裂延伸率为10%，抗拉强度为57 MPa，而PLA/SL15和PLA/SL20的紫外线阻挡性能优于其他复合材料，其紫外线透射率低于10%。添加ASL至PLA中可增加疏水性，所有PLA/ASL复合材料的水接触角均较高。使用2,2-二苯基-1-苯基苦肼测定了PLA/SL复合材料的抗氧化性能，其中PLA/SL20复合材料的自由基清除活性最佳，达到80%。此外，我们还应用人结肠癌细胞（HCT-15）和胃上皮细胞（NCC-24）对PLA/SL复合材料进行了体外抗氧化活性和细胞相容性分析。通过H2O2暴露试验和活/死细胞分析，证实了PLA/SL复合材料对细胞的保护作用。此外，所有PLA/SL和PLA/ASL复合材料相比于PLA，均能促进细胞增殖。其中，PLA/SL5和PLA/SL10的细胞增殖最为突出。最后，所有PLA/SL和PLA/ASL复合材料的溶血率均低于2%。本研究的结果表明，木素/PLA复合材料具有良好的抗氧化性能、细胞相容性和血液相容性，适用于潜在的生物医学应用。

In this study, acetylated soda lignin (ASL) and non-acetylated soda lignin (SL) were extruded with PLA in different concentrations to fabricate antioxidant polylactic acid (PLA)/lignin composites for potential biomedical applications. After lignin acetylation, good compatibility was observed between PLA and lignin in scanning electron microscopy images. All the PLA/ASL composites displayed higher mechanical properties than PLA/SL composites. PLA/ASL5 displayed the highest mechanical characteristics with elongation at break of 10% and tensile strength of 57 MPa, while PLA/SL15 and PLA/SL20 demonstrated superior UV-blocking potential with UV transmittance less than 10%. Addition of ASL in PLA lead to an increase in the hydrophobic character, with all the PLA/ASL displaying a higher water contact angle. The antioxidant test using 2,2-diphenyl-1-picrylhydrazyl assay showed that PLA/SL composites rendered superior radical scavenging activity (RSA), with PLA/SL20 composites displaying an RSA of 80%. Furthermore, in vitro antioxidant activity and cytocompatibility were analyzed using human colon cancer cells (HCT-15) and gastric epithelial cells (NCC-24). In vitro antioxidant activity, evaluated by H2O2 exposure was confirmed by a live/dead assay. PLA/SL composites protected both types of cells from oxidative stress. In addition, all PLA/SL and PLA/ASL composites promoted cell proliferation compared to PLA. PLA/SL5 and PLA/SL10 displayed the highest cell proliferation of all composites. Lastly, all PLA/SL and PLA/ASL composites had a hemoglobin release less than 2%. The antioxidant properties, cytocompatibility, and hemocompatibility of lignin/PLA demonstrated in our study indicate that these lignin/PLA composites possess the desirable attributes for potential biomedical applications.