覆盖时间：2012年至2023年人类人口老龄化。 因此，各种疾病的最大风险因素，如糖尿病，癌症和神经退行性疾病，在全球范围内增加。 老龄化相关疾病通常不是单独发生的，而是由多因素引起的，并且需要整体性方法来识别和解析可能治疗方法的作用方式。 随着C. elegans变为老龄化的主要模型生物，研究人员现在拥有了一种强大的体内工具，用于识别和研究影响寿命和健康寿命的药物。 自然产物一直是研究的焦点。 本综述文章涵盖了过去十年（2012年至2023年）的重要发展，其中发现了C. elegans中具有健康老化特性的自然产物。 我们（i）讨论了对蠕虫老化的自然产物的影响的知识状态，包括方法，测定和参与途径; （ii）分析了有关自然化合物的文献，以其分子性质和对哺乳动物效果的可转化性为依据; （iii）检查了关于多组分混合物的文献，特别关注研究的生物体，提取方法以及有关其化学成分和生物活性成分的表征的努力。 （iv）我们进一步提议结合小型体内模型生物，如C. elegans和复杂的分析方法（“wormomics”），以引导分解具有抗衰老特性的复杂自然产物的途径。

Covering: 2012 to 2023The human population is aging. Thus, the greatest risk factor for numerous diseases, such as diabetes, cancer and neurodegenerative disorders, is increasing worldwide. Age-related diseases do not typically occur in isolation, but as a result of multi-factorial causes, which in turn require holistic approaches to identify and decipher the mode of action of potential remedies. With the advent of C. elegans as the primary model organism for aging, researchers now have a powerful in vivo tool for identifying and studying agents that effect lifespan and health span. Natural products have been focal research subjects in this respect. This review article covers key developments of the last decade (2012-2023) that have led to the discovery of natural products with healthy aging properties in C. elegans. We (i) discuss the state of knowledge on the effects of natural products on worm aging including methods, assays and involved pathways; (ii) analyze the literature on natural compounds in terms of their molecular properties and the translatability of effects on mammals; (iii) examine the literature on multi-component mixtures with special attention to the studied organisms, extraction methods and efforts regarding the characterization of their chemical composition and their bioactive components. (iv) We further propose to combine small in vivo model organisms such as C. elegans and sophisticated analytical approaches ("wormomics") to guide the way to dissect complex natural products with anti-aging properties.