植物来源的多酚是广泛分布在植物中的天然化合物。由于其抗氧化、抗炎、抗癌、心脏保护和神经作用等潜在的健康益处，它们在食品和制药行业受到了更多关注。口服多酚化合物可以被用作多种治疗的辅助，但由于其化学不稳定性，使用受到了限制。该综述讨论了多酚的不同结构组成及其对化学稳定性的影响。尽管具备潜力和广泛的应用，但需要改进多酚的传递，以实现针对人类肠道的精确定位，避免大规模的化学修饰。由多酚形成的口服给药不可行，因为它具有不稳定性、低生物可及性和有限生物利用度。基于多糖（淀粉、果胶、壳聚糖和纤维素）的纳米递送系统被认为是一种可行的选择，可以增强口服效果，并实现对特定组织的直接控制输送。时间和剂量可以个体化精确控制，以适应肠癌等特定疾病的需求。本综述将讨论基于多糖纳米结构系统的机制，以保护多酚化合物免受降解，并增强其在肠道的渗透性和口服生物利用度，同时还将探讨多糖作为纳米载体在多酚化合物的控制和靶向输送中的潜在应用。

Plant-derived polyphenols are naturally occurring compounds widely distributed in plants. They have received greater attention in the food and pharmaceutical industries due to their potential health benefits, reducing the risk of some chronic diseases due to their antioxidant, anti-inflammatory, anticancer, cardioprotective, and neuro-action properties. Polyphenolic compounds orally administered can be used as adjuvants in several treatments but with restricted uses due to chemical instability. The review discusses the different structural compositions of polyphenols and their influence on chemical stability. Despite the potential and wide applications, there is a need to improve the delivery of polyphenolics to target the human intestine without massive chemical modifications. Oral administration of polyphenols is unfeasible due to instability, low bioaccessibility, and limited bioavailability. Nano-delivery systems based on polysaccharides (starch, pectin, chitosan, and cellulose) have been identified as a viable option for oral ingestion, potentiate biological effects, and direct-controlled delivery in specific tissues. The time and dose can be individualized for specific diseases, such as intestinal cancer. This review will address the mechanisms by which polysaccharides-based nanostructured systems can protect against degradation and enhance intestinal permeation, oral bioavailability, and the potential application of polysaccharides as nanocarriers for the controlled and targeted delivery of polyphenolic compounds.