一对印裔美国人来到我们的诊所，他们有原发性不孕和反复的试管婴儿失败的病史。男性是一名睾丸癌幸存者，患有勃起功能障碍和无精症。女性伴侣患有多囊卵巢综合征（PCOD）。她在另一家生育诊所进行了三次胚胎移植，未成功。在我们的诊所，她接受了控制性卵巢刺激，从月经第二天开始使用rFSH（促卵泡激素）然后使用HMG（人绝经期促性腺激素）进行抗拮抗协议，接着进行了胚胎的植入前基因筛查。随后，她开始了ERA周期的激素替代治疗（HRT）协议，从第二天开始，同时在第七天进行了宫腔镜检查。在进行了五天的孕酮补充后，她进行了全子宫内膜活检以进行ERA（子宫内膜可接受性鉴定）。在和前一次ERA周期相同的HRT协议下，进行了冻胚移植周期。胚胎移植后，给予了激素免疫治疗和两周一次的静脉脂肪乳剂。怀孕测试呈阳性，BHCG值为290 mIU/mL。在孕39周完成后，她顺产。在男性和女性因素并存的情况下，逐步个体化的治疗方案会最大化成功的机会。结合检查患者宫腔镜、ERA和免疫调节的胚胎替代治疗（ICSI）以及胚胎植入前的基因筛查，冷冻或新鲜精子的使用取得了积极的结果。

A couple of Indo-American descent, presented to our clinic with a history of primary infertility and repeated IVF implantation failure. Male was a testicular cancer survivor who had erectile dysfunction and azoospermia. Female partner had polycystic ovarian syndrome (PCOD). She had three unsuccessful attempts of embryo transfer at another fertility clinic. At our clinic, she underwent controlled ovarian stimulation, COH started from day two period with rFSH (follicle stimulating hormone) followed by HMG (human menopausal gondadotropin) with antagonist protocol followed by preimplantation genetic screening of embryos. Subsequently, she began HRT (hormone replacement Therapy) protocol for ERA cycle from day 2, where she also underwent hysteroscopy on day 7. After five days of progesterone supplementation, she underwent endometrial biopsy for ERA (endometrial receptivity assay). Frozen embryo transfer cycle was started with the same HRT protocol used in her previous ERA cycle. Post embryo transfer, immunotherapy with steroids and fortnightly intralipids was given. Pregnancy test was positive with a BHCG value of 290 mIU/mL. and she delivered naturally after 39 completed weeks of gestation. A stepwise personalized treatment approach maximizes the chances of a successful outcome in presence of both male and female factors. Frozen or fresh sperms for ICSI with PGS along with hysteroscopy, ERA and under cover of immune modulation yielded positive results.