银屑病是一种全身性炎症性疾病，主要表现为皮肤病变，但炎症也可能影响关节和眼睛。很多与银屑病相关的合并症已经被描述出来，包括代谢综合征和冠状动脉斑块。银屑病的发病机制是多方面的。遗传和免疫因素在激发炎症过程中起到了一定作用。遗传易感性与HLA-C*06:02风险等位基因和细胞因子（如肿瘤坏死因子阿尔法、白细胞介素17、白细胞介素20、白细胞介素23和干扰素阿尔法）引起的炎性反应有关。除了常规治疗如局部类固醇和免疫抑制剂外，生物制剂在银屑病、银屑病性关节炎和合并的葡萄膜炎的治疗中被广泛使用。在大多数情况下，生物制剂对葡萄膜炎具有益处，但在某些情况下，其中一些药物可能会导致严重的副作用，威胁到视力。 版权所有 © 2023 Elsevier Inc. 发表。

Psoriasis is a systemic inflammatory disorder, manifested mainly by skin lesions, but the inflammation may affect also the joints and eye. Many comorbidities were described in association with psoriasis, including metabolic syndrome and coronary plaques. The pathomechanism of psoriasis is multifaceted. Both genetic and immunologic aspects play a role in stimulating inflammation. Genetic susceptibility is conditioned by presence of the HLA-C*06:02 risk allele and the inflammatory reaction secondary to cytokines, like tumor necrosis factor alfa (TNF-alfa), interleukin-17 (IL-17), interleukin-20 (IL-20), interleukin-23 (IL-23) and interferon alfa. Besides the conventional therapy as topical steroids and immunosupresants, biologic therapies are widely used in the treatment of psoriasis, psoriatic arthritis and coexisting uveitis. In the majority of cases biologic therapy has beneficial effect on uveitis, but in some cases, some of these drugs can lead to serious side effects threatening vision.Copyright © 2023. Published by Elsevier Inc.