癌症是全球死亡的主要原因之一。一些新兴技术正在帮助对抗癌症。癌症治疗在杀死癌细胞方面已经取得了一定的效果，但仍有大部分患者每年死于这种疾病。因此，更加积极的原发癌治疗方法被采用，并显示出可以挽救更多的生命。最近的研究通过采用物理方法改变肿瘤生物学来推进癌症治疗领域。它使用微泡增强辐射效应，通过损害肿瘤血管后导致肿瘤细胞死亡。该技术能够通过调整超声场以刺激微泡，并将其局限于肿瘤体积，以避免对周围组织的血管损伤。因此，超声刺激微泡（USMB）的这种新应用可以作为一种新型的癌症治疗方法，通过导致血管破坏从而导致肿瘤细胞死亡。与放射疗法联合使用USMB已经显示出增强放射疗法的抗血管作用，从而实现了增强肿瘤反应。最近的纳米泡研究表明，可以渗入细胞内部空间，将这种新的治疗方法扩展到进一步改善基于超声的治疗的可能性。局部肿瘤细胞的显著增强杀伤意味着可以在较低的放射剂量下使基于放射的治疗更加有效。这种技术可以显著提高放射治疗的效果，并减少正常组织的毒性反应，对放射肿瘤学实践产生更大的影响。本综述文章总结了USMB增强放射治疗的过去和最新进展。该综述主要关注临床前的发现，但也强调了一些在癌症治疗中使用USMB作为治疗方式的临床研究发现。版权所有 © 2023 作者。由 Elsevier GmbH 发布。保留所有权利。

Cancer is one of the leading causes of death worldwide. Several emerging technologies are helping to battle cancer. Cancer therapies have been effective at killing cancer cells, but a large portion of patients still die to this disease every year. As such, more aggressive treatments of primary cancers are employed and have been shown to be capable of saving a greater number of lives. Recent research advances the field of cancer therapy by employing the use of physical methods to alter tumor biology. It uses microbubbles to enhance radiation effect by damaging tumor vasculature followed by tumor cell death. The technique can specifically target tumor volumes by conforming ultrasound fields capable of microbubbles stimulation and localizing it to avoid vascular damage in surrounding tissues. Thus, this new application of ultrasound-stimulated microbubbles (USMB) can be utilized as a novel approach to cancer therapy by inducing vascular disruption resulting in tumor cell death. Using USMB alongside radiation has showed to augment the anti-vascular effect of radiation, resulting in enhanced tumor response. Recent work with nanobubbles has shown vascular permeation into intracellular space, extending the use of this new treatment method to potentially further improve the therapeutic effect of the ultrasound-based therapy. The significant enhancement of localized tumor cell kill means that radiation-based treatments can be made more potent with lower doses of radiation. This technique can manifest a greater impact on radiation oncology practice by increasing treatment effectiveness significantly while reducing normal tissue toxicity. This review article summarizes the past and recent advances in USMB enhancement of radiation treatments. The review mainly focuses on preclinical findings but also highlights some clinical findings that use USMB as a therapeutic modality in cancer therapy.Copyright © 2023 The Author(s). Published by Elsevier GmbH.. All rights reserved.