乳腺癌（BC）涉及复杂的信号传递网络，其特点是多个信号级联之间和之内的广泛交流和反馈环路。其中许多信号通路由于癌基因和/或抑癌基因的遗传改变驱动，并受各种环境刺激的影响。我们描述了非受体酪氨酸激酶（NRTK）PYK2在BC中的信号传递整合和反馈环路中的独特作用。PYK2在各种级联中作为一个信号中枢功能，并且其参与正向和负向反馈环路增强了信号的稳健性，调节了信号的动力学，并对BC的生长、上皮-间质转化（EMT）、干性、迁移、侵袭和转移做出贡献。我们还讨论了PYK2作为各种BC亚型的治疗靶点的潜力。版权所有 © 2023 Elsevier Ltd. 保留所有权利。

Breast cancer (BC) involves complex signaling networks characterized by extensive cross-communication and feedback loops between and within multiple signaling cascades. Many of these signaling pathways are driven by genetic alterations of oncogene and/or tumor-suppressor genes and are influenced by various environmental cues. We describe unique roles of the non-receptor tyrosine kinase (NRTK) PYK2 in signaling integration and feedback looping in BC. PYK2 functions as a signaling hub in various cascades, and its involvement in positive and negative feedback loops enhances signaling robustness, modulates signaling dynamics, and contributes to BC growth, epithelial-to-mesenchymal transition (EMT), stemness, migration, invasion, and metastasis. We also discuss the potential of PYK2 as a therapeutic target in various BC subtypes.Copyright © 2023 Elsevier Ltd. All rights reserved.