美国的乳腺癌发病率和死亡率与种族有关的差异已有充分记录。遗传血统对乳腺癌的肿瘤基因组、危险因素、治疗和结果差异的影响尚不明确。癌症基因组图谱（TCGA）是一个公开可用的资源，它为最近出现的研究提供了可能性，以血统为基础对肿瘤DNA和蛋白质表达进行表征，同时还包括人种和种族的社会构建。基于TCGA的研究结果支持以往的临床证据，表明具有非洲血统的美国妇女患有侵袭性生物学特征和较差结果的乳腺癌的可能性较高，相比其他背景的妇女。基于TCGA的数据研究表明，亚裔妇女的肿瘤有良好的免疫微环境，并可能经历较好的无病存活，相比白人美国妇女。由于样本数量较少，TCGA对于西班牙裔/拉丁裔患者的数据有限。总体而言，TCGA为定义导致乳腺癌差异的分子、生物学和生殖遗传因素提供了重要机会。© 2023年。外科肿瘤学协会。

Race-related variation in breast cancer incidence and mortality are well-documented in the United States. The effect of genetic ancestry on disparities in tumor genomics, risk factors, treatment, and outcomes of breast cancer is less understood. The Cancer Genome Atlas (TCGA) is a publicly available resource that has allowed for the recent emergence of genome analysis research seeking to characterize tumor DNA and protein expression by ancestry as well as the social construction of race and ethnicity. Results from TCGA based studies support previous clinical evidence that demonstrates that American women with African ancestry are more likely to be afflicted with breast cancers featuring aggressive biology and poorer outcomes compared with women with other backgrounds. Data from TCGA based studies suggest that Asian women have tumors with favorable immune microenvironments and may experience better disease-free survival compared with white Americans. TCGA contains limited data on Hispanic/Latinx patients due to small sample size. Overall, TCGA provides important opportunities to define the molecular, biologic, and germline genetic factors that contribute to breast cancer disparities.© 2023. Society of Surgical Oncology.