随着全球造血干细胞移植（HSCT）的数量越来越多，HSCT后存活率的增加，以及HSCT对幸存者、照料者和家庭产生深远的身体、心理和情感影响，有必要确定可能有助于或支持移植后创伤性增长（PTG）的因素。本研究旨在调查澳大利亚长期异基因HSCT幸存者中PTG的普遍性，并描述PTG与相关临床、社会人口学和心理学变量之间的关联。这是一项涵盖澳大利亚HSCT幸存者的大型、多中心、横断面调查，邀请2000年至2012年间在新南威尔士州接受移植的所有人参与。受访者完成了PTG量表（PTGI）、悉尼BMT后调查、FACT-BMT量表、DASS 21量表、慢性移植物抗宿主病（GVHD）活动评估-患者自述（B表）、李氏慢性GVHD症状量表和恐惧癌症复发量表。数据分析采用独立样本t检验、单因素方差分析和Pearson相关分析，并进行分层多重回归，调整潜在混杂因素，并确定解释变量与PTG的独立相关性。在441名受访者中，99%报告了某种程度的PTG，其中67%报告了中度到高水平的PTG。女性、年轻年龄、辅助治疗使用、焦虑、心理压力和心理社会护理，以及更高的生活质量与更高水平的PTG有关。重要的是，我们还发现PTG与慢性GVHD或HSCT后发病率无关。在这项研究中，也是目前最大规模的关于长期异基因HSCT幸存者的PTG研究中，我们发现成长似乎是普遍存在的，99%的幸存者报告了某种程度的PTG，其中67%报告了中高水平的PTG。重要的是，我们发现PTG与GVHD或慢性HSCT后身体病态、不利的财务、职业或性影响无关。这表明正是HSCT本身的必要性和经历促进了个人成长。因此，医疗保健专业人员应该意识到HSCT的深刻而广泛的影响以及幸存者可能会经历的PTG程度。确定可能帮助HSCT幸存者应对和增强抗逆力的干预措施至关重要。© 2023. BioMed Central Ltd., part of Springer Nature.

Given the increasing number of Hematopoietic Stem Cell Transplantations (HSCT) performed world-wide, the increasing likelihood of survival following HSCT, and the profound physical, psychosocial, and emotional impact of HSCT on survivors, their carers and families, it is important to identify factors that may contribute to or support post-traumatic growth (PTG) after transplant. In this study, we aimed to investigate the prevalence of PTG in an Australian cohort of long-term allogeneic HSCT survivors and describe associations between PTG and relevant clinical, sociodemographic and psychological variables.This was a large, multi-centre, cross sectional survey of Australian HSCT-survivors inviting all those transplanted in New South Wales between 2000 and 2012. Respondents completed the PTG Inventory (PTGI), the Sydney Post-BMT Survey, FACT-BMT, DASS 21, The Chronic Graft versus Host Disease (GVHD) Activity Assessment-Patient Self-Report (Form B), the Lee Chronic GVHD Symptom Scale, and the Fear of Cancer Recurrence Scale. Data was analysed using independent t-tests, one-way analysis of variance, and pearson's correlations, and hierarchical multiple regression adjusted for potential confounders and to ascertain independent associations of explanatory variables with PTG.Of 441 respondents, 99% reported some level of PTG with 67% reporting moderate to high levels of PTG. Female gender, younger age, complementary therapy use, anxiety, psychological distress and psychosocial care, and higher quality of life were associated with higher levels of PTG. Importantly, we also found that PTG was not associated with either chronic GVHD or post-HSCT morbidity.In this study - the largest study of PTG in long-term allogeneic HSCT survivors - we found that growth appears ubiquitous, with 99% of survivors reporting some degree of PTG and 67% reporting moderate-high levels of PTG. Importantly, we found no association with GVHD or chronic physical post-HSCT morbidity, or adverse financial, occupational or sexual impacts. This suggests that it is the necessity for and experience of, HSCT itself that foments personal growth. Accordingly, healthcare professionals should be alert to the profound and wide-ranging impact of HSCT - and the degree to which survivor's may experience PTG. Identifying interventions that may assist HSCT survivors cope and building their resilience is of utmost importance.© 2023. BioMed Central Ltd., part of Springer Nature.