长链非编码RNA（lncRNA）是一类转录RNA分子，长度超过200个核苷酸，没有编码蛋白的潜能。它们能与DNA、RNA和蛋白质发生反应。因此，它们参与在表观遗传、转录、转录后以及翻译水平上的基因表达调控。已经证实，lncRNA在人类恶性肿瘤和预后结果中起到重要作用。在本综述中，我们将全面而详细地讨论一种新鉴定的lncRNA——位于人类2q13染色体上的lncRNA WAPPH，在各种癌症中的作用。越来越多的研究表明，lncRNA AWPPH 在不同的恶性肿瘤中发生异常表达，包括乳腺癌、胃癌、结直肠癌、卵巢癌、膀胱癌、白血病等。lncRNA WAPPH 在肿瘤发生和发展中起着促癌基因的作用。此外，lncRNA AWPPH 参与了实体瘤和血液肿瘤的许多生物过程。综上所述，在我们的深入分析基础上，lncRNA AWPPH可以被视为人类恶性肿瘤的潜在生物标志物或治疗靶点。 侵权必究© Bentham Science Publishers；有任何问题，请发送邮件至epub@benthamscience.net。

Long non-coding RNAs (lncRNAs) are transcribed RNA molecules longer than 200 nucleotides in length that have no protein-coding potential. They are able to react with DNA, RNA, and protein. Hence they involve in regulating gene expression at the epigenetic, transcriptional, post-transcriptional, and translational levels. LncRNAs have been proven to play an important role in human malignancies and prognostic outcomes. In this review, we will comprehensively and functionally discuss the role of a novel identified lncRNA, namely lncRNA WAPPH located on human chromosome 2q13, in various cancers. Increasing research studies have shown that lncRNA AWPPH is deregulated in different malignancies, including breast cancer, gastric cancer, colorectal cancer, ovarian cancer, bladder cancer, leukemia, and others. LncRNA WAPPH serves as an oncogene in tumorigenesis and the development of cancer. Moreover, lncRNA AWPPH is involved in numerous biological processes of solid and blood cancers. Taken together, based on our scrutiny analysis, lncRNA AWPPH can be regarded as a putative biomarker for diagnosis or therapeutic target in human malignancies.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.