乳腺癌患者在存活率提高后通常会经历与治疗相关的障碍。高强度间歇训练（HIIT）已成为一种对成年癌症患者具有潜力的运动疗法。然而，对HIIT在乳腺癌患者中的整体效果仍然稀缺且存在争议。因此，我们进行了一项系统综述和荟萃分析，全面评估了HIIT对乳腺癌患者健康相关结果的影响。我们从PubMed、Embase和Web of Science数据库中检索了从成立以来至2022年11月7日的相关文献。符合条件的研究包括将HIIT干预与常规护理（UC）或中等强度有氧运动（MICT）比较的随机对照试验。主要评估指标是身体适应性，探索性结果包括体组成、血液生物标志物和患者报告的结果。提取总结数据，并计算标准化均值差异（SMD）进行荟萃分析。对于不能合并的结果，进行了系统综述。我们的分析包括了10个研究的19篇文章，涵盖了符合纳入标准的532名参与者。荟萃结果表明，HIIT在改善峰值摄氧量（VO2peak）方面优于UC。VO2peak（L/min）和VO2peak（mL/kg/min）的SMD分别为0.79（95% CI 0.13，1.45）和0.59（95% CI 0.01，1.16）。 HIIT组与MICT组之间的VO2peak没有显著差异。对身体组成和血液生物标志物的荟萃分析显示，HIIT与UC之间没有显著差异。系统综述表明，HIIT对肌肉力量、疲劳和情绪健康有积极影响。HIIT是提高VO2peak的时效性替代方案，还可以增强肌肉力量，缓解疲劳和情绪症状，适用于乳腺癌患者。在乳腺癌治疗中，应将HIIT作为运动处方的重要组成部分。需要进一步进行更大队列的研究，以确定HIIT引起的变化对乳腺癌患者其他结果的临床意义。© 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

Women with breast cancer and improved survival often experience treatment-related impairments. High-intensity interval training (HIIT) has emerged as a promising exercise therapy modality for adult cancer patients. However, the overall effects of HIIT in breast cancer patients remain scarce and controversial. Therefore, we conducted a systematic review and meta-analysis to comprehensively evaluate the impact of HIIT on health-related outcomes in breast cancer patients.We searched the PubMed, Embase, and Web of Science from inception to November 7, 2022. Eligible studies included randomized controlled trials that compared HIIT interventions with usual care (UC) or MICT in breast cancer patients. The primary outcome assessed was physical fitness, and exploratory outcomes included body composition, blood-borne biomarkers, and patient-reported outcomes. Summary data were extracted, and standardized mean differences (SMD) were calculated for meta-analysis. For outcomes that could not be pooled, a systematic review was conducted.Our analysis included 19 articles from 10 studies, encompassing 532 participants who met the inclusion criteria. Pooled results demonstrated that HIIT was superior to UC in improving peak oxygen uptake (VO2peak ). The SMD for VO2peak (L/min) and VO2peak (mL/kg/min) was 0.79 (95% CI 0.13, 1.45) and 0.59 (95% CI 0.01, 1.16), respectively. No significant differences in VO2peak were found between the HIIT and MICT groups. Meta-analyses on body composition and blood-borne biomarkers showed no significant differences between HIIT and UC. Systematic review indicated favorable effects of HIIT on muscle strength, fatigue, and emotional well-being.HIIT is a time-efficient alternative to MICT for improving VO2peak and may also enhance muscle strength and alleviate fatigue and emotional symptoms in breast cancer patients. HIIT should be considered as an important component of exercise prescription in breast cancer care. Further studies with larger cohorts are needed to determine the clinical significance of HIIT-induced changes in terms of other outcomes in women with breast cancer.© 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.