通过多模式化热化学治疗，在体内使用复合阿霉素介孔碳纳米球可有效地抑制肿瘤淋巴转移。
Combined Doxorubicin Mesoporous Carbon Nanospheres for Effective Tumor Lymphatic Metastasis by Multi-Modal Chemo-Photothermal Treatment in vivo.
发表日期：2023
作者：
Yipengchen Yin, Jiaxin Sun, Tiaoyan Jiang, Li Zhu, Wenchao Gu, Sheng Wang, Le Song, Changchun Wang, Qin Zhang
来源：
International Journal of Nanomedicine
摘要：
哨兵淋巴结（SLN）是肿瘤细胞转移的第一个区域性淋巴结，其识别和治疗对于预防肿瘤转移具有重要意义。然而，目前用于识别和治疗SLN的临床方法仍然远未令人满意，原因是高昂的成本、侵入性和低准确性。我们旨在设计一种新型纳米医学系统，用于高效的SLN成像和治疗。我们设计并制备了空心介孔碳球（HMCS），并将其负载了化疗药物阿霉素（DOX），然后通过聚乙烯吡咯烷酮（PVP）改性，获得纳米医学品：HMCS-PVP-DOX。尺寸约为150纳米的HMCS-PVP能够长时间停留在淋巴结中，并染色淋巴结，肉眼观察即可。同时，HMCS-PVP具有出色的光声和光热成像能力，实现了对淋巴结的多模态成像定位。由于其较高的比表面积，HMCS可以大量负载化疗药物阿霉素（DOX）。HMCS-PVP-DOX在1064纳米激光照射下具有显著的光热效应，实现了细胞和动物实验中淋巴转移的高效协同化疗-光热疗法。HMCS-PVP-DOX还显示出良好的稳定性和生物安全性。多功能纳米医学品HMCS-PVP-DOX有望为设计诊断和治疗淋巴转移的纳米医学提供新的范例，因其良好的稳定性和安全性。© 2023 Yin et al.
Sentinel lymph node (SLN) is the first regional lymph node where tumor cells metastasize, and its identification and treatment are of great significance for the prevention of tumor metastasis. However, the current clinical modalities for identification and treatment of SLN are still far from satisfactory owing to their high cost, invasiveness and low accuracy. We aim to design a novel nanomedicine system for SLN imaging and treatment with high efficacy.We designed and prepared hollow mesoporous carbon spheres (HMCS) and loaded with the chemotherapeutic drug doxorubicin (DOX), which is then modified with polyvinyl pyrrolidone (PVP) to obtain nanomedicine: HMCS-PVP-DOX.HMCS-PVP with a size of about 150 nm could retain in the lymph nodes for a long time and stain the lymph nodes, which could be easily observed by the naked eye. At the same time, HMCS-PVP exhibited excellent photoacoustic and photothermal imaging capabilities, realizing multimodal imaging to locate lymph nodes precisely. Due to its high specific surface area, HMCS could be largely loaded with the chemotherapeutic drug doxorubicin (DOX). HMCS-PVP-DOX displayed highly efficient synergistic chemotherapy-photothermal therapy for lymphatic metastases in both cellular and animal experiments due to its significant photothermal effect under 1064 nm laser irradiation. HMCS-PVP-DOX also displayed great stability and biosafety.Multifunctional nanomedicine HMCS-PVP-DOX is expected to provide a novel paradigm for designing nanomedicine to the diagnosis and treatment of lymphatic metastases because of its good stability and safety.© 2023 Yin et al.