研究动态
Articles below are published ahead of final publication in an issue. Please cite articles in the following format: authors, (year), title, journal, DOI.

乳腺癌中血小板的进展。

The Progress of Platelets in Breast Cancer.

发表日期:2023
作者: Luchang Wang, Kaijiong Zhang, Jia Feng, Dongsheng Wang, Jinbo Liu
来源: Cell Death & Disease

摘要:

乳腺癌是最常见的女性癌症,也是第六大致命原因,严重影响女性的生活质量。血小板是由巨核细胞产生的碎片之一,由于其抗凝功能,已越来越多地被肿瘤研究人员所研究。根据相关研究,作为循环内与血管生成相关因子的关键来源,血小板能够调节肿瘤血管生成和血管的完整性,同时也能影响肿瘤微环境,从而促进肿瘤细胞的增殖与分化。血小板能够通过覆盖或转移正常的MHC I分子到肿瘤细胞上,保护肿瘤细胞免受免疫系统的杀伤并促进肿瘤细胞转移。然而,有关涉及的机制细节仍然不清楚。本文回顾并分析了血小板在肿瘤发生、肿瘤细胞增殖、肿瘤转移和癌症治疗中的作用研究,为读者提供了对相关研究的更好理解。© 2023 Wang et al.
Breast cancer is the most common female cancer and the sixth leading cause of death, seriously affecting the quality of life of women. Platelets, one of the fragments derived from megakaryocytes, are being increasingly investigated by tumor researchers because of their anticoagulant function. According to relevant studies, platelets, as the key source of circulating angiogenesis-related factors, can regulate tumor angiogenesis and vascular integrity, and they can also affect the tumor microenvironment, thereby facilitating the proliferation and differentiation of tumor cells. By covering or transferring normal MHC I molecules to tumor cells, platelets can protect tumor cells from being killed by the immune system and facilitate tumor cell metastasis. However, details on the mechanisms involved have remained elusive. This paper reviews and analyzes studies of the role of platelets in tumorigenesis, tumor cell proliferation, tumor metastasis, and cancer treatment to provide readers with a better understanding of the relevant studies.© 2023 Wang et al.