为了研究地中海生活方式与英国人群全因死亡率、癌症死亡率和心血管疾病（CVD）死亡率之间的关联，我们对来自英国生物库队列中年龄在40至75岁之间、从2009年至2012年期间没有心血管疾病或癌症，并进行了至2021年的随访的110,799名个体进行了研究。地中海生活方式通过地中海生活方式（MEDLIFE）指数进行基线评估，该指数由生活方式问卷和饮食评估得出，包括三个部分：（1）“地中海食物消耗”，（2）“地中海饮食习惯”，以及（3）“体育锻炼、休息、社交习惯和共享”。死亡信息从死亡登记记录中获取。我们使用Cox回归模型分析了研究关联。在中位数为9.4年的随访期内，鉴定到了4247例总死亡病例，2401例癌症死亡病例和731例CVD死亡病例。与MEDLIFE指数第一四分位相比，逐渐增加的四分位具有的全因死亡风险比（HR）分别为0.89（95% CI, 0.81至0.97）、0.81（95% CI, 0.74至0.89）和0.71（95% CI, 0.65至0.78）（P趋势<.001，对于全因死亡风险）。对于癌症死亡率，四分位数的HR为0.90（95% CI, 0.80至1.01）、0.83（95% CI, 0.74至0.93）和0.72（95% CI, 0.64至0.82）（P趋势<.001）。所有MEDLIFE指数的部分块与全因死亡和癌症死亡的风险降低有独立关联，而第3部分与CVD死亡的风险降低有关。地中海生活方式的较高遵循与英国中老年成年人的全因死亡率和癌症死亡率呈剂量反应关联。采用适应非地中海人群的当地特色的地中海生活方式可能是一种健康生活方式的一部分。版权所有 © 2023 Mayo Foundation for Medical Education and Research。Elsevier Inc. 发表并保留所有权利。

To examine the association between the Mediterranean lifestyle and all-cause, cancer, and cardiovascular disease (CVD) mortality in a British population.We studied 110,799 individuals 40 to 75 years of age from the UK Biobank cohort, free of CVD or cancer between 2009 and 2012 who were followed-up to 2021. The Mediterranean lifestyle was assessed at baseline through the Mediterranean Lifestyle (MEDLIFE) index, derived from the lifestyle questionnaire and diet assessments and comprising three blocks: (1) "Mediterranean food consumption," (2) "Mediterranean dietary habits," and (3) "physical activity, rest, social habits, and conviviality." Death information was retrieved from death register records. Cox regression models were used to analyze the study associations.During a median 9.4-year follow-up, 4247 total deaths, 2401 cancer deaths, and 731 CVD deaths were identified. Compared with the first quartile of the MEDLIFE index, increasing quartiles had HRs of 0.89 (95% CI, 0.81 to 0.97), 0.81 (95% CI, 0.74 to 0.89), and 0.71 (95% CI, 0.65 to 0.78) (P-trend<.001 for all-cause mortality). For cancer mortality, the quartiles had HRs of 0.90 (95% CI, 0.80 to 1.01), 0.83 (95% CI, 0.74 to 0.93), and 0.72 (95% CI, 0.64 to 0.82) (P-trend<.001). All MEDLIFE index blocks were independently associated with lower risk of all-cause and cancer death, and block 3 was associated with lower CVD mortality.Higher adherence to the Mediterranean lifestyle was associated with lower all-cause and cancer mortality in British middle-aged and older adults in a dose-response manner. Adopting a Mediterranean lifestyle adapted to the local characteristics of non-Mediterranean populations may be possible and part of a healthy lifestyle.Copyright © 2023 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.