先兆子痫是全球孕产妇及胎儿发病率和死亡率的主要原因之一。其并发症不仅包括了子痫发作、颅内出血，还有晚期心血管疾病等。结合临床和危险因素变量，以及多个生物标志物的组合有助于临床医生对先兆子痫妇女进行风险分层和预后预测。我们评估了基质金属蛋白酶-9（MMP-9）和抑制肿瘤原性2（ST2）的作为生物标志物的有效性，并用于预测先兆子痫患者的母婴结局。这项前瞻性队列研究涉及49例先兆子痫患者和80例健康对照组。生物标志物通过酶联免疫吸附试验在血浆中测量。随访患者以评估母婴结局。先兆子痫组的MMP-9均值为2.42 ng/mL，对照组为2.67 ng/mL。先兆子痫组的ST2均值为1937.4 ± 747.81，高于对照组的1005.7 ± 683.6，并且差异显著（P = 0.0001）。研究人群根据MMP-9和ST2的高低被分为两组。MMP-9水平较低似乎与早发先兆子痫和晚发先兆子痫有关。ROC（接受者操作特征）曲线无法预测母婴结局。本研究表明，先兆子痫妇女的MMP-9水平较低，ST2水平较高，与健康孕妇相比。但是，这两个生物标志物都无法预测先兆子痫的并发症。© 2023 Elsevier Ltd. 保留所有权利。

Preeclampsia is one of the major causes of maternal and foetal morbidity and mortality worldwide. Its complications include but are not limited to eclampsia, intracerebral haemorrhage and cardiovascular diseases in the later stages of life. The combination of clinical and risk variables and a panel of multiple biomarkers will help clinicians in risk stratification and prognostication of clinical outcomes among preeclamptic women. We evaluated MMP-9 (matrix metalloproteinase - 9) and ST2 (suppression of tumorigenicity 2) for utility as biomarkers and for predicting maternal and foetal outcomes in women with preeclampsia.This prospective cohort study involved 49 preeclamptic women and 80 healthy controls. Biomarkers were measured in plasma using ELISA. The patients were followed up to assess maternal and foetal outcomes.The mean value of MMP-9 was 2.42 ng/mL in the preeclamptic group and 2.67 ng/mL in controls. The mean value of ST2 (1937.4 ± 747.81) in the preeclamptic group was high compared to the control group (1005.7 ± 683.6) and the difference was significant (P = 0.0001). The study population was divided into those with high and low MMP-9 and those with high and low ST2. Lower levels of MMP-9 seemed to be related to both early and late onset preeclampsia. The ROC (Receiver Operating Characteristic) curve did not show the ability to predict maternal and foetal outcomes.Our study demonstrated that women with preeclampsia had low MMP-9 and high ST2 compared to healthy pregnant women. But neither of the biomarkers could predict complications of preeclampsia.Copyright © 2023 Elsevier Ltd. All rights reserved.