在癌症治疗领域，数十年来取得了显著进展。尽管如此，仍然存在许多重大挑战，包括多药耐药、药物不稳定和副作用。为了克服这些问题的障碍，各种类型的材料在生物医学研究中被探索。其中，天然化合物的应用由于其出色的生物活性而迅速增长。天然化合物，尤其是多酚化合物，在癌症治疗中起着积极而重要的作用。单宁酸（TA）作为最着名的多酚之一，在癌症治疗领域以其独特的结构、物理化学性质、药理学、抗癌、抗病毒、抗氧化等强大生物特性吸引了广泛关注。本综述首先集中讨论了TA在调节肿瘤信号通路中的基本结构和重要作用，然后着重探讨了TA在化疗和纳米粒子、水凝胶等制剂的制备中的应用。此外，还讨论了TA / Fe3 + 复合物涂层在光热疗法、化学动力疗法、联合治疗和治疗诊断一体化方面的应用。版权所有 © 2023 作者。Elsevier Masson SAS 发布。保留所有权利。

Significant advancements have been noticed in cancer therapy for decades. Despite this, there are still many critical challenges ahead, including multidrug resistance, drug instability, and side effects. To overcome obstacles of these problems, various types of materials in biomedical research have been explored. Chief among them, the applications of natural compounds have grown rapidly due to their superb biological activities. Natural compounds, especially polyphenolic compounds, play a positive and great role in cancer therapy. Tannic acid (TA), one of the most famous polyphenols, has attracted widespread attention in the field of cancer treatment with unique structural, physicochemical, pharmaceutical, anticancer, antiviral, antioxidant and other strong biological features. This review concentrated on the basic structure along with the important role of TA in tuning oncological signal pathways firstly, and then focused on the use of TA in chemotherapy and preparation of delivery systems including nanoparticles and hydrogels for cancer therapy. Besides, the application of TA/Fe3+ complex coating in photothermal therapy, chemodynamic therapy, combined therapy and theranostics is discussed.Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.