癌细胞、内皮细胞、炎症细胞和各种细胞因子共同构成肿瘤微环境（TME）。趋化因子是细胞因子家族中最大的一类，主要由肿瘤细胞和TME中的炎症细胞分泌。它们通过促进肿瘤生长和转移、血管生成以及靶向炎症细胞的化学吸引，在肿瘤的发展和进展中发挥重要作用。目前，一些趋化因子受体拮抗剂正在临床试验中用作靶向抗肿瘤药物。本文通过近期发表的文章，综述了趋化因子在恶性肿瘤发展和进展中的作用，并考虑了以趋化因子和受体为靶点的新型抗肿瘤治疗策略。版权所有 © 2023 Elsevier Ltd. 保留所有权利。

Cancer cells, endothelial cells, inflammatory cells and various cytokines form a part of the tumor microenvironment (TME). Chemokines constitute the largest family of cytokines, and are mainly secreted by tumor cells and inflammatory cells in the TME. They play an important role in tumor development and progression by promoting tumor growth and metastasis, angiogenesis, and targeting the chemoattraction of inflammatory cells. Currently, some chemokine receptor antagonists are being used in clinical trials as targeted anti-tumor drugs. In this article, we review the roles of chemokines in the development and progression of malignant tumors based on recently published papers, taking into consideration of the new anti-tumor therapeutic strategies targeting chemokines and receptors.Copyright © 2023 Elsevier Ltd. All rights reserved.